Evaluation of Network-based Function Prediction Algoritluns on Oryza sativajaponica Protein-Protein Interaction Data

Abstract

Protein-protein interactions (PPIs) in an organism can be represented as a computational network and can be used to predict unknown protein functions using appropriate algorithms. This method is shown to outperform other computational techniques using human data, Several such network-based function predictions exist but the majority of these have only been evaluated on well-annotated species such as yeast and humans.