University of Colombo e-Repository

UCER (University of Colombo Electronic Repository) is a collection of scientific research publications by researchers at the University of Colombo, Sri Lanka. This e-Repository serves to manage, preserve and make available the academic works of the faculty, postgraduate students, and research groups. The collection includes faculty publications, master's and doctoral theses abstracts. This repository is updated regularly, and new works are added to collections on a continuous basis

Guidelines

Authors are responsible for obtaining copyright permission from the publisher and submitting the signed declaration to ir@lib.cmb.ac.lk.

Recent Submissions

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    A comparative chromatography study of different Tel Spp. (Ipomoea Spp.) in Kuliyapitiya region, Kurunegala District, Sri Lanka
    (Faculty of Indigenous Medicine, University of Colombo, 2014) Wijayasinghe, L.S.G.; Dissanayake, D.M.H.D.B.; Priyadarshani, A.I.S.; Perera, P.K.
    "Tel" (Ipomoea species, Family Convolulacea) is a vine growing commonly in South Asia, East Africa, Asia Pacific and ...
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    Ayurveda treatment regimens for Osteoarthritis: A comprehensive review
    (University of Colombo, 2019) De Silva, R.H.S.K.; Perera, P.K.; Galppatty, P.
    Osteoarthritis (OA) has become a burden globally for the healthcare sector due to its high prevalence and incidence. There are numerous drug treatments for OA in allopathic medicine. However, their efficiency and adverse effect ...
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    Polycystic ovarian syndrome in patients with schizophrenia treated with atypical anti-psychotics: A case control study
    (Cambridge University Press, 2017) De Silva, V.; Senanayake, A.; Ratnatunga, S.S.; Dissanayake, S.; Gamage, S.; De Silva, S.; Hanwella, Raveen; Wijeyaratne, C.
    Objective: Objective was to compare the prevalence of probable polycystic ovarian syndrome (PCOS) in females treated with atypical anti-psychotics with normal controls. Aims: To compare the prevalence of PCOS in patients treated with atypical anti-psychotics and normal controls. To study the hormone profiles in these two groups. Methods: Cases consisted of 102 reproductive age females with schizophrenia treated with atypical anti-psychotics for ≥6 months and had gained ≥10% body weight. Control group was 123 age and BMI matched females. Menstrual history, physical examination for hirsuitism, acne, androgenic alopecia, anthropometrics measures, Ultrasound abdomen and hormone analysis were done. Results: Mean age of cases = 33.17 years (SD 8.9) and controls = 33.08 years (SD 5.6). Mean BMI of cases = 25.92 (SD 5.2) and controls = 25.03 (SD 4.3). Polycystic ovarian morphology of ovaries on ultra sound scan was significantly more in cases 49 (48%) than controls 16 (13.%) (P < 0.001). Probable PCOS was significantly more in atypical anti-psychotic treated females (n = 22, 21.56%) than in normal controls (n = 10, 8.13%) (P = 0.04). Atypical anti-psychotic treated patients with PCOS had significantly lower mean LH levels 6.69 mIU/L than those without PCOS 10.30 (P = 0.35). There was no significant difference in testosterone, FSH, prolactin, TSH and free T4 levels. Conclusion: Treatment with atypical anti-psychotics is associated with higher prevalence of PCOS. This has not been reported previously. The hormonal profile in these patients may be different with low testosterone and LH levels.
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    Pharmacological effects of Pterocarpus marsupium
    (BLDE University Journal of Health Sciences, 2024) Basnayake, Pradeepa Isurumali; Gunatilake, Mangala
    Pterocarpus marsupium (PM) (Gammalu in Sinhala) is a member of the Fabaceae family. It is a large deciduous tree, indigenous to Sri Lanka, India, and Nepal. Due to its therapeutic benefits, PM is regarded as a medicinal plant in Ayurveda and for industrial products. This narrative review focuses on the pharmacological effects of PM, its’ bioactive compounds, biological effects, and toxicity. For this, literature was gathered via Google Scholar (102), PubMed (89), ScienceDirect (22), published books, web pages, and personal communication (13). The remaining literature was selected after the elimination of 14 duplicates. Titles and abstracts were considered, and some studies were excluded due to insufficient data and irrelevance. After this screening, 133 papers were removed. A total of 66 articles were selected by reading the abstracts that report the pharmacological effects of PM. The main keywords used were PM, Gammalu, Indian kino, hytochemicals, antidiabetic, hypoglycaemic, anti‑dyslipidaemic, antioxidant, anti‑inflammation, anti‑diarrhoeal, anti‑cataract, and toxicity
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    Zebrafish, Danio Rerio as a Replacement Alternative Model Useful in CKDu Experiments
    (Springer, 2018) Gunatilake, Mangala
    Zebrafish (Danio rerio) and its embryo has become a popular replacement alternative among the scientists because of many scientific attributes. As it is a model commonly used in ecotoxicology, our plan is to use this model to identify causative factors leading to chronic renal disease of unknown origin prevailing among poor, farming communities in Sri Lanka. This paper describes briefly the training underwent at University of Antwerp, Belgium and how zebrafish model could be used to address an important public health issue in Sri Lanka.