Profound thrombocytopenia and generalized hyperpigmentation following pyrimethamine use
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Sri Lanka college of pediatricians
Abstract
Pyrimethamine is an effective anti-parasitic
medication with a narrow therapeutic index. We
report a child with toxoplasmosis who developed
hyperpigmentation and profound thrombocytopenia
during a course of treatment with pyrimethamine.
These two unusual complications occurred in
addition to folate deficiency and megaloblastic
anaemia which are recognized adverse effects of this
medication.
Pyrimethamine is an effective anti-parasitic medication with a narrow therapeutic index. We report a child with toxoplasmosis who developed hyperpigmentation and profound thrombocytopenia during a course of treatment with pyrimethamine. These two unusual complications occurred in addition to folate deficiency and megaloblastic anaemia which are recognized adverse effects of this medication
Pyrimethamine is an effective anti-parasitic medication with a narrow therapeutic index. We report a child with toxoplasmosis who developed hyperpigmentation and profound thrombocytopenia during a course of treatment with pyrimethamine. These two unusual complications occurred in addition to folate deficiency and megaloblastic anaemia which are recognized adverse effects of this medication
Description
Keywords
Pyrimethamine, profound thrombocytopenia, hyperpigmentation
Citation
Senanayake, M. P., Mettananda, D. S. G., & Vidyatilake, S. (2011). Profound thrombocytopenia and generalized hyperpigmentation following pyrimethamine use. Sri Lanka Journal of Child Health, 40, 134-135.