Chemistry and Bioactivity of Physciaceae Lichens Pyxine consocians and Heterodermia leucomelos

Abstract

Cabraleadiol monoacetate, atranorin, methyl-P-orcinolcarboxylate, zeorin, 4-0-methylcryptoclilorophaeic acid, and lichexanthone were isolated from the lichen Pyxine consocians Vainio. Helerodermici leucomelos (L). Poelt contained a new triterpenoid, 6a-hydroxyhop-21pH-22(29)- en, along with atranorin, zeorin, glyceryl trilinolate, and 3,6-dimethyl-2-hydroxy-4-methoxybenzoic acid. Cabraleadiol monoacetate, 4-0-methylcryptochlorophaeic acid, lichexanthone. and 3,6-dimethyl-2-hydroxy-4-methoxybenzoic acid showed mosquito larvicidal activity against the second instar larvae of Aedes acgypti. Lichexanthone exhibited human sperm motility enhancmg activity.