The sequential analysis of binary responses: a score test for the case of three time points
| dc.contributor.author | Sooriyarachchi, M.R. | |
| dc.contributor.author | Whitehead, J. | |
| dc.contributor.author | Whitehead, A. | |
| dc.contributor.author | Bolland, K.M. | |
| dc.date.accessioned | 2021-07-07T03:29:30Z | |
| dc.date.available | 2021-07-07T03:29:30Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three xed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for strati cation are discussed | en_US |
| dc.description.sponsorship | Welcome Trust | en_US |
| dc.identifier.citation | Sooriyarachchi, M.R., Whitehead, J., Whitehead, A., Bolland, K. The sequential analysis of binary responses: a score test for the case of three time points. Statistics in Medicine 25, 2196-2214, 2005. | en_US |
| dc.identifier.uri | http://archive.cmb.ac.lk/handle/70130/5490 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.subject | binary data; longitudinal data; repeated observations; score test; sequential clinical trial | en_US |
| dc.title | The sequential analysis of binary responses: a score test for the case of three time points | en_US |
| dc.type | Article | en_US |