Design and development of Ayurvedic Shadanga Panaya as a comprehensible novel dosage form

Abstract

Shadanga Panaya, an Ayurvedic formulation comprising six raw materials (Cyperus rotundus L, Fumaria parviflora Lam, Vetiveria zizanoides L, Santalum album L, Pavonia odorata Willd, and Zingiber officinale Roscoe) known as Kashaya (Decoction), has diverse traditional uses, including treating fever, Pitta dosha imbalance, detoxification, dehydration conditions and COVID-19 symptoms. The lack of standardization and quality parameters, the development of a modern, comprehensible dosage form. This study aimed to achieve this by reviewing the literature, preparing it according to classical methods, and utilizing spray drying without or with Maltodextrin. The evaluation involved assessing solubility, physicochemical traits, and organoleptic properties, some essential standardization tests such as total ash (8.70%), acid insoluble ash (6.25%), water-soluble ash (10.80%), and moisture (1.25%) were calculated according to WHO-2012 guidelines. The final product, a spray-dried powder with adding only Maltodextrin without any other excipient, met Ayurvedic standards, with a pH of 6.77, refractive index of 0.4, and specific gravity of 1.10. This approach aims to enhance Shadanga Panaya's acceptability without compromising safety. The research team believes that with this new method and standardization process, Shadanga Panaya can be developed into a modern, comprehensible dosage form, potentially benefiting health in contemporary contexts.