A Review of Patakaranjadi Decoction, used in Grahani Roga

Abstract

Grahani roga is a digestive disorder commonly correlated to the irritable bowel syndrome in modern medicine. In Ayurveda Grahani roga is a one of Maha roga and Patakaranjadi decoction has been used for the treatment of Grahani roga. It included Pata, Karanja, Puuthikaranja, Pippali, Pippalimoola, Chavya, Chitraka, Shunti, Kalashaka, Harithaki, Pila, Bilva. This study has focused to explore the pharmacodynamic and pharmacokinetic properties of Patakaranjadi decoction for treating Grahani roga, a condition marked by digestive issues and malabsorption. The data has been collected, from monographs, research articles, books and the results revealed that significant pharmacodynamic characteristics, including a dominant Katu rasa (66.67%) and prominent Guna is Laghu guna (91.67%). Further, ingredients of decoction’s having Ushna veerya (100%) while the Vipaka of Katu (75%). Additionally, the therapeutic actions such as Deepana (91.66%, Pachana (91.66%), Shothahara (100%), Krimihara (100%), and Rasayana (58.33%) illustrate a holistic approach to managing Grahani roga, addressing both symptoms and underlying imbalances. Findings suggest that decoction Katu rasa stimulates digestive activity, Laghu guna enhances metabolic functions, the majority of the studied ingredients exhibit Ama pachana and Agni dipana properties, which help address the underlying causes of Grahani roga. These properties work by detoxifying Ama, stimulating the digestive fire, and correcting digestive imbalances, thereby eliminating the etiological factors associated with the condition. Although the results highlight the decoction's potential as an effective treatment option, further clinical research is needed to confirm its efficacy and safety. This study underscores the value of combining traditional medicinal practices with modern scientific research, positioning Patakaranjadi decoction as a promising intervention for digestive disorders.