Renal Pathology in systemic Lupus Erythematosus: a clinic-pathological study

Abstract

of 5oo renal biopsies parformed between January 1990 to December 1ggo, 32 biopsies were from patients having systemic Lupus Erythematosus (SLE). The male to femelc ratio of sLE patients was 1 :7. The mean age of the males was 34 y"ur., and of the famales 27 years. The histological pattern varied between normal glomeruli to extensive glomerulosclerosis. Each type of glomerulonephritis was classified according to the modified World Health Organization (WHO) Classif ication. 14o/o ol the patlents had histologically nornlal glomeruli (wHo class l), 1go//o had mesangial nephropathv (WHo Class ll), 18% had focal segmental tyge of glomerulonephritis (WHO CLss lll ), 41 9/o had diffuse proliferative glomerulonephritis (wHo class lv), 4% had membranous nephroparhy (wHo class v), ahd 4yo had extensive glomerulosclerosis (wHo class Vl). Although the value of renal biopsy has been questioned we* conclude that it is a most importan investfgation in the management of lupus nephritis