A Review of Shadangapana and it’s Therapeutic Approach

Abstract

Shadangapana is a classical ayurvedic polyherbal formulation described in the Sharangadhara Samhita under Kwatha kalpana. It is composed of six herbal ingredients: Musta (Cyperus rotundus), Parpataka (Oldenlandia corymbosa), Ushira (Vetiveria zizanoides), Chandana (Santalum album), Udichaya (Plectranthus zatarhendi) and Nagara (Zingiber officinale). Traditionally, this formulation has been used for managing conditions such as Jwara (fever), Pipasa (excessive thirst) and Daha (burning sensation). This study has been focused to identify pharmacodynamic properties and pharmacokinetic potentials of ingredients of Shadangapana and to find out its therapeutic action on various ailments. Data has been collected from classical Ayurvedic texts, modern pharmacological references, dictionaries and relevant scholarly journals. The results revealed predominance of Tikta Rasa, Laghu and Ruksha guna, Sheeta veerya and Katu vipaka. All six ingredients exhibited Kapha shamana activity while majority of ingredients demonstrated Pitta shamana potential. The formulation comprises significant Deepana, Pachana and KaphaMedho-vishoshana properties. Shadangapana acts as an antipyretic hydrating detoxifying agent enhancing metabolic activities of various systems of the human body as neuro protective, nerve tonic, anti-inflammatory, anti-bacterial, anti-allergic, hepatoprotective, blood purifying formulation. Moreover, recent research advances revealed Shadangapana is effective in managing fever, excessive thirst, and burning sensation. Additionally, it helps to alleviate obstruction in the Swedavaha srotas. Further Shadangapana supports its potential role in managing dyslipidemia, dehydration, and post-COVID multisystem inflammatory syndrome (MIS). These findings highlight the potential of Shadangapana as a foundation for developing effective therapeutic formulations further.