Abstract:
This study was carried out to determine the seroprevalence of rubella antibodies in children
1- 11 years of age and pregnant females,and factors associated with rubella seroprevalence
in the Kalutara district of Sri Lanka.The proportion of women in the child bearing age group
and the community susceptible to rubella infection in selected years for different
immunisation strategies was estimated.The average precentage of children protected against
rubella was 13 per cent (range 6 per cent-25 per cent) whereas 76 per cent (range 71 per
cent-82 per cent) of the pregnant females were found to be protected against rubella.The
findings of the community survey indicated that the susceptibility to rubella infection among
children was significantly associated with age, ethnicity,schooling (where school children
were less likely to be susceptible to rubella than childern not attending school), year in
school birth order of the child,number of children in the family,father's education and
number of persons in the family. However, in the multivariate model only age, father's
education and number of persons in the household were significant predicators of
seroprevalence.The averge annual risk of natural infection was estimated to be 2-3
infections per 100 susceptible in the population based on seroprevalence data of
children.The median age of natural rubella infection estimated from the average annual risk
of infection was 25 years.Based on the results of the simulation studies, it is recommended
that the strategy of selective immunisation of females at 12 years of age for 10 years and
immunisation of all children at 1 1/2 years be adopted.This strategy may be supplemented or
modified depending on the feasibility of implementing such a strategy and the objective and
needs of the programme.
