Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder

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dc.contributor.author Weerakoon, W.A.S.S.
dc.contributor.author Perera, P.K.
dc.contributor.author Gunasekera, D.
dc.contributor.author Suresh, T.S.
dc.date.accessioned 2024-09-26T08:51:30Z
dc.date.available 2024-09-26T08:51:30Z
dc.date.issued 2018
dc.identifier.citation Weerakoon, W.A.S.S., Perera, P.K., Gunasekera, D., & Suresh, T.S. (2018). Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/6743862. en_US
dc.identifier.uri https://doi.org/10.1155/2018/6743862
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7340
dc.description.abstract Sudarshana powder (SP) is one of the most effective Ayurveda powder preparations for paediatric febrile conditions. The objective of the present study was to evaluate the in vitro and in vivo antioxidant potentials of SP. The in vitro antioxidant effects were evaluated using ABTS radical cation decolourization assay where the TROLOX equivalent antioxidant capacity (TEAC) was determined. The in vivo antioxidant activity of SP was determined in Wistar rats using the Lipid Peroxidation (LPO) assay in serum. The in vitro assay was referred to as the TROLOX equivalent antioxidant capacity (TEAC) assay. For the in vivo assay, animals were dosed for 21 consecutive days and blood was drawn to evaluate the MDA level. The in vitro antioxidant activity of 0.5 𝜇g of SP was equivalent to 14.45 𝜇g of standard TROLOX. The percentage inhibition against the radical formation was 50.93 ± 0.53%. The SP showed a statistically significant (𝑝 < 0.01) decrease in the serum level of thiobarbituric acid-reactive substance in the test rats when compared with the control group. These findings suggest that the SP possesses potent antioxidant activity which may be responsible for some of its reported bioactivities. en_US
dc.language.iso en en_US
dc.publisher Evidence-Based Complementary and Alternative Medicine en_US
dc.subject In Vitro antioxidant en_US
dc.subject In Vivo antioxidant en_US
dc.subject Sudarshana Powder en_US
dc.subject paediatricfebrilecondition en_US
dc.title Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder en_US
dc.type Article en_US


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