Abstract:
Sudarshana powder (SP) is one of the most effective Ayurveda powder preparations for paediatric febrile conditions. The objective of
the present study was to evaluate the in vitro and in vivo antioxidant potentials of SP. The in vitro antioxidant effects were evaluated
using ABTS radical cation decolourization assay where the TROLOX equivalent antioxidant capacity (TEAC) was determined.
The in vivo antioxidant activity of SP was determined in Wistar rats using the Lipid Peroxidation (LPO) assay in serum. The
in vitro assay was referred to as the TROLOX equivalent antioxidant capacity (TEAC) assay. For the in vivo assay, animals were
dosed for 21 consecutive days and blood was drawn to evaluate the MDA level. The in vitro antioxidant activity of 0.5 𝜇g of SP was
equivalent to 14.45 𝜇g of standard TROLOX. The percentage inhibition against the radical formation was 50.93 ± 0.53%. The SP
showed a statistically significant (𝑝 < 0.01) decrease in the serum level of thiobarbituric acid-reactive substance in the test rats when
compared with the control group. These findings suggest that the SP possesses potent antioxidant activity which may be responsible
for some of its reported bioactivities.
