dc.contributor.author |
Pallie, M.S. |
|
dc.contributor.author |
Perera, P.K. |
|
dc.contributor.author |
Goonasekara, C.L. |
|
dc.contributor.author |
Kumarasinghe, K.M.N. |
|
dc.contributor.author |
Arawwawala, L.D.A.M. |
|
dc.date.accessioned |
2024-09-26T05:52:41Z |
|
dc.date.available |
2024-09-26T05:52:41Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
Pallie, M.S., Perera, P.K., Goonasekara, C.L., Kumarasinghe, K.M.N., and Arawwawala, L.D.A.M. (2017). Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant. American Journal of Ethnomedicine, 4(1:5). https://doi.org/10.21767/2348-9502.100005 |
en_US |
dc.identifier.issn |
2348-9502 |
|
dc.identifier.uri |
https://doi.org/10.21767/2348-9502.100005 |
|
dc.identifier.uri |
http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7329 |
|
dc.description.abstract |
Background: Due to several toxic effects of synthetic diuretics drugs, people relay
of medicinal plants as a source of diuretics. Hence, the efficacy of Tragia spp.
which belonging to plant family Euphorbiaceae is an important medicinal plant
used as a diuretic in Sri Lanka.
Objective: The aim of the present study was to investigate diuretic activity and
standardize whole plant of Tragia spp.
Materials and methods: Plant extract (doses of 550, 1100, 1650, 2200 mg/kg),
vehicle (2 ml of distilled water), reference drug (furosemide at 13 mg/kg) were
given orally to separate groups of Wistar male rats (N = 6). In order to assess the
diuretic activity, urine output was measured hourly for five hours. Na+ and K+
content, specific gravity, pH of urine measured in all groups. Whole plant of Tragia
spp. was standardized in terms of physico-chemical parameters, phytochemical
screening and antioxidant activity.
Results: Results revealed that urine output of rats were significantly (P<0.05)
increased when increasing the dose of Tragia spp. extract. Diuretic activity was
initiated in the first hour and declined with time. Diuresis was maximum at the
1 h and at a dose of 2200 mg/kg urine output was significantly (P<0.05) higher
than the reference drug. Tragia spp. extract also triggered a clear increase in Na+
and K+ levels and decreased pH levels in urine. Physico-chemical parameters,
phytochemical screening and antioxidant activity were determined in order to
standard Tragia spp.
Conclusion: Tragia spp. exhibit marked diuretic activity and its mechanism of
action is similar to a loop diuretic drug. Further, establishment of standardization
parameters of Tragia spp. will help in correct identification and prevent
adulteration. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
American Journal of Ethnomedicine |
en_US |
dc.subject |
Tragia spp |
en_US |
dc.subject |
Diuresis |
en_US |
dc.subject |
Phytochemicals |
en_US |
dc.subject |
Standardization |
en_US |
dc.title |
Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant |
en_US |
dc.type |
Article |
en_US |