Abstract:
In order to establish the biological importance of hydroxamic acids derivatives the acid
dissociation constants (ionization constants) were determined by potentiometric and
spectroscopic methods. The possible correlation of the experimental values with theoretical
values was examined using Gaussian 98 suit, hi potentiometric method the data were analyzed
by three analytical procedures such as Bjerrum method, Irving and Rossotti method and
Sarkar and Kruck method. It has been found that the pKa values obtained by these three
methods are in good agreement with each other. The modified limiting absorption method
was used to calculate the ionization constants in spectroscopic method. In the case of Nsubstituted
hydroxamic acids, the relative order of pKa values in 1:1 ethanol is as follows:
