Abstract:
To compare the effectiveness of rFSH (Gonal F) with hMG
(Pergonal) in IVF and ICSI cycles. Method:
The biological and clinical outcomes of two age matched
samples from women using Gonal F and Pergonal were
analyzed. The total numbet of FSH vials used in a
stimulation cycle, numbet of eggs retrieved, fertilization rates
and number of pregnancies were analyzed. Results:
There was no statistically significant difference between the
mean numbers of FSH vials used (FSH = 45.5 yials Vs
h M G = 39.7 vials, P> 0.05) There was no significant
difference between the mean number of eggs retrieved.
(rFSH = 7 8 Vs fiMG = 7.7, P>0.05). The mean remiization
rate was significantly higher with hM G compared to rFSH
(hMG=75.0% Vs rFSH = 56.8%, P<0.05)
Clinical pregnancy rates were higher in rFSH group (23.7%)
when compared to hM G group (13.2%), but this was not
statistically significant. (x2= 1.40, df= 1, p>0.05)
The cycle cancellation rates due to inadequate stimulation
were similar in both groups (0.5%)
Conclusion:
Biological out comes of both rFSH and hM G ate
comparable. Type of FSH used appears to be one of the
factors determining clinical outcome. Further evaluation
in this tegard is recommended.
