Abstract:
A 33-year old primigravida who has been married for 3
years and investigated fot subfertility was transferred from
the teaching hospital - Galle at a POA of 18 weeks with
mild bleeding PV. Ultrasound diagnosis of viable cervical
presnancv had been made and >hc was given two doses
of merhotTixate before transfer to oui unit. \\c gave two
more doses of methotrixate and she aborted her babv
and had a massive haemorrhage.
Setting:
Department of Obstetrics and Gynaecology, Faculty of
Medicine, Colombo.
Method:
Consecutive non-pregnant normal women seeking
treatment for male infertility were recruited for
assessment of fasting blood glucose, C and T G
concentrations. Age matched pregnant women who
underwent the 75g Oral Glucose Tolerance Test (OGTT)
between 20 - 24 weeks of gestation based on identified
risk factors for diabetes mellitus were recruited
concurrently and their fasting plasma C and T G
concentrations were measured.
Results:
45 consenting non-pregnant women and 95 consenting
pregnant women referred for OGT T were recruited. All
non-pregnant women had normal fasting blood glucose
concentrations (mean 97.7 +/- 1.6 mg/dl). 50/95
pregnant women had normal OGT T and 45 had
abnormal OGT T based on WH O criteria. The mean
age of non- pregnant women was 33.2 +/- 2.1 and among
pregnant women 30.2 +/- 1.2 (p = 0.07).
Non-pregnant women had a fasting plasma C of 215 +/
-12 mg/dl and T G of 94.9 +/- 8.2. mg/dl. Pregnant
women with normal OGT T vs. abnormal OGT T had
fasting C 239.2 +/- 7.2 mg/dl vs. 218 +/- 17.2 mg/dl (p
= 0.05); and fasting T G of201.6 +/- 8 mg/dl vs. 180.9
+/-11.3 mg/dl (p • 0.06). Anova single factor comparison
of non-pregnant women and pregnant women with
normal and abnormal OGT T revealed a significant
elevation of fasting C andTG in normal pregnant women
(p = 0.04).
Conclusion:
A significant elevation of fasting C and T G
concentrations occur in normal pregnancy; while
abnormal glucose tolerance in pregnancy does not confer
an additional risk on plasma lipid concentrations.
