Sex Difference in Risk Factors, GRACE Scores, and Management among Post-Acute Coronary Syndrome Patients in Sri Lanka

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dc.contributor.author Galappatthy, Priyadarshani
dc.contributor.author Bataduwaarachchi, Vipula
dc.contributor.author Ranasinghe, Priyanga
dc.contributor.author Galappatthy, Gamini
dc.contributor.author Senerath, Upul
dc.contributor.author Wijeyaratne, Chandrika
dc.contributor.author Ekanayake, Ruwan
dc.date.accessioned 2021-09-02T06:06:16Z
dc.date.available 2021-09-02T06:06:16Z
dc.date.issued 2020
dc.identifier.citation Galappatthy, P., Bataduwaarachchi, V., Ranasinghe, P., Galappatthy, G., Senerath, U., Wijeyaratne, C., & Ekanayake, R. (2020). Sex Difference in Risk Factors, GRACE Scores, and Management among Post-Acute Coronary Syndrome Patients in Sri Lanka. Cardiology Research and Practice, 2020. en_US
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5854
dc.description.abstract Objective. To assess sex-based differences in the prevalence of risk factor, their management, and differences in the prognosis among acute coronary syndrome (ACS) in Sri Lanka. Methods. Patients diagnosed with ACS were recruited from hospitals throughout the island. The Joint European Societies guidelines were used to assess recommended targets for coronary heart disease risk factors, and the GRACE score was used to assess the post-ACS prognosis. Age-adjusted regression was performed to calculate odds ratios for men versus women in risk factor control. Results. A total of 2116 patients, of whom 1242 (58.7%) were men, were included. Significant proportion of women were nonsmokers; OR = 0.11 (95% CI 0.09 to 0.13). The prevalence of hypertension (), diabetes (), and dyslipidemia () was higher in women. The LDL-C target was achieved in a significantly higher percentage of women (12.6%); OR = 0.33 (95% CI 0.10 to 1.05). When stratified by age, no significant differences were observed in achieving the risk factor targets or management strategies used except for fasting blood sugar () where more men achieved control target in both age categories. Majority of the ACS patients had either high or intermediate risk for one-year mortality as per the GRACE score. In-hospital and 1-year mean mortality risk was significantly higher among men of less than 65 years of age (). Conclusions. Smoking is significantly lower among Sri Lankan women diagnosed with ACS. However, hypertension, diabetes, and dyslipidemia were more prevalent among them. There was no difference in primary and secondary preventive strategies and management in both sexes but could be further improved in both groups en_US
dc.language.iso en en_US
dc.publisher Hindawi en_US
dc.title Sex Difference in Risk Factors, GRACE Scores, and Management among Post-Acute Coronary Syndrome Patients in Sri Lanka en_US
dc.type Article en_US


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