Abstract:
Birthweight predicts health later in life and is influenced by inherited factors. We investigated the association of the c.61G > A,
and c.2566G > A polymorphisms in the epidermal growth factor (EGF) gene [GenBank NM_001963] with birthweight in three
groups of healthy pregnant women, and in women with pregnancies affected by fetal growth restriction (FGR). Subjects comprised 171 Sinhalese women with normal pregnancies (Group A), 64 white Western European women with normal pregnancies
(Group B), 101 white Western European women with normal pregnancies and their babies (Group C) and 107 women with pregnancies affected by FGR, their partners and their babies (Group D). Maternal EGF genotypes were associated with birthweight of
healthy babies of women in Groups A (P 5 0.03), B (P 5 0.001) and C (P 5 0.01). The association persisted following adjustment
for confounding by gestational age, sex, maternal weight, parity and smoking habit. The trend from heaviest to lightest birthweights in all these groups was c.61AA > c.61GA > c.61GG and c.2566GG > c.2566GA > c.2566AA. The EGF haplotype associated with lower birthweight (c.61G, c.2566A) was transmitted at increased frequency from heterozygous parents to babies
affected by FGR in Group D (P 50.02). These findings support the hypothesis that growth factors expressed by the feto-maternal
unit affect birthweight, and implicates polymorphism in the EGF gene in the aetiology of birthweight variability.