Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes

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dc.contributor.author Katugampala, Supun
dc.contributor.author Perera, Inoka C.
dc.contributor.author Nanayakkara, Chandrika
dc.contributor.author Perera, Theshini
dc.date.accessioned 2021-07-07T03:31:24Z
dc.date.available 2021-07-07T03:31:24Z
dc.date.issued 2018
dc.identifier.citation Supun Katugampala, Inoka C. Perera, Chandrika Nanayakkara, Theshini Perera, "Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes", Bioinorganic Chemistry and Applications, vol. 2018, Article ID 2530851, 7 pages, 2018. https://doi.org/10.1155/2018/2530851 en_US
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5503
dc.description.abstract Metallotriazine complexes possess interesting biological and medicinal properties, and the present study focuses on the synthesis, characterization, and antimicrobial activity of four novel copper-triazine derivatives in search of potent antibacterial and antifungal drug leads. In this study, 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4′-disulfonic acid monosodium salt (L1, ferrozine) and 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5,5′-disulfonic acid disodium salt (L2, ferene) have been used as ligands to study the complexation towards copper(II). The synthesized complexes, [CuCl2(ferrozine)]·7H2O·MeOH (1), [CuCl2(ferrozine)2]·5H2O·MeOH (2), [CuCl2(ferene)]·H2O·MeOH (3), and [CuCl2(ferene)2]·H2O·MeOH (4), have been characterized spectroscopically, and preliminary bioassays have been carried out. FTIR spectroscopic data have shown that N=N and C=N stretching frequencies of complexes have been shifted towards lower frequencies in comparison with that of the ligands, confirming new bond formation between Cu and N, which in turn lowers the strength of N=N and C=N bonds. In addition, a bathochromic shift has been observed for UV-visible spectra of complexes (1), (2), (3), and (4). Furthermore, elemental analysis data have been useful to obtain empirical formulas of these complexes and to establish the purity of each complex. Complexes (1) and (2) have shown antibacterial activity for both S. aureus (ATCC® 25923) and E. coli (ATCC® 25922) at 1 mg/disc concentration, and ferrozine has shown a larger inhibition zone against the clinical sample of C. albicans at 1 mg/disc concentration in comparison with the positive control, fluconazole. en_US
dc.language.iso en en_US
dc.title Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes en_US
dc.type Article en_US


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