The sequential analysis of binary responses: a score test for the case of three time points

Sooriyarachchi, M.R.; Whitehead, J.; Whitehead, A.; Bolland, K.M.

dc.contributor.author	Sooriyarachchi, M.R.
dc.contributor.author	Whitehead, J.
dc.contributor.author	Whitehead, A.
dc.contributor.author	Bolland, K.M.
dc.date.accessioned	2021-07-07T03:29:30Z
dc.date.available	2021-07-07T03:29:30Z
dc.date.issued	2005
dc.identifier.citation	Sooriyarachchi, M.R., Whitehead, J., Whitehead, A., Bolland, K. The sequential analysis of binary responses: a score test for the case of three time points. Statistics in Medicine 25, 2196-2214, 2005.	en_US
dc.identifier.uri	http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5490
dc.description.abstract	In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three xed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for strati cation are discussed	en_US
dc.description.sponsorship	Welcome Trust	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley	en_US
dc.subject	binary data; longitudinal data; repeated observations; score test; sequential clinical trial	en_US
dc.title	The sequential analysis of binary responses: a score test for the case of three time points	en_US
dc.type	Article	en_US