Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes

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dc.contributor.author Abeydeera, Nalin
dc.contributor.author Perera, Inoka C.
dc.contributor.author Perera, Theshini
dc.date.accessioned 2021-06-29T05:45:42Z
dc.date.available 2021-06-29T05:45:42Z
dc.date.issued 2018
dc.identifier.citation Nalin Abeydeera, Inoka C. Perera, Theshini Perera, "Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes", Bioinorganic Chemistry and Applications, vol. 2018, Article ID 7563820, 7 pages, 2018. https://doi.org/10.1155/2018/7563820 en_US
dc.identifier.uri https://doi.org/10.1155/2018/7563820
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5429
dc.description.abstract Four Zn(II) complexes containing a pyridyl triazine core (L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl2]·5H2O·ZnCl2 (1), [Zn(L1)2Cl2]·4H2O·2CH3OH (2), [Zn(L2)Cl2]·3H2O·CH3OH (3), and [Zn(L2)2Cl2] (4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and 1H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes 1–4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 1–4 with bovine serum albumin (BSA) resulted binding constants (Kb) of 3.09 × 104 M−1, 12.30 × 104 M−1, and 16.84 × 104 M−1 for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins. en_US
dc.language.iso en en_US
dc.title Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes en_US
dc.type Article en_US


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