Immunostimulatory activity of Sri Lankan wild type Carica papaya L. mature leaf concentrate in a rat model.

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dc.contributor.author Jayawardhane, N D C K K
dc.contributor.author Jayasinghe, C D
dc.contributor.author Vivehananthan, K
dc.contributor.author Udagama, P V
dc.date.accessioned 2021-06-16T03:52:51Z
dc.date.available 2021-06-16T03:52:51Z
dc.date.issued 2014
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5390
dc.description.abstract Modulation of the immune system by plant based immunomodualtors is well accepted. The present study evaluated the immunomodulatory activity of the mature leaf concentrate (MLC) of Carica papaya Sri Lankan wild type variant, to fill an existing knowledge gap. Separate groups of albino Wistar rats (N=6) were orally administered with 3 doses (low: 0.18, mid: 0.36 and high: 0.72 ml/100 g body weight) of the MLC and distilled water as the control for 3 consecutive days. Selected nonfunctional and functional immunological parameters were determined at the 3rd day post treatment using standard methodology. Liver and kidney functional parameters were determined to assess the acute hepato and renal toxicities, respectively. The MLC elicited significant immunostimulatory activity for both nonfunctional and functional immunological assays. Rat platelet count was significantly (P<0.05) increased by all three doses at post treatment while total WBC, monocyte, lymphocyte and bone marrow cell counts were significantly (P<0.05) increased by mid and high doses of the MLC. Conversely, no significant (P>0.05) difference was observed for splenocyte counts in treated rats. The phagocytic activity based on functional assay was significantly (P<0.05) increased by all three doses compared to the control. Further, the oral administration of the MLC neither provoked acute hepato or renal toxicities. Thus, the present study confirmed that mature leaf concentrate (MLC) of Carica papaya Sri Lankan wild type variant is orally active and effectively stimulates the nonfunctional and functional immunological parameters tested with no acute liver and kidney toxicities. en_US
dc.description.sponsorship Financial assistance by the Collaborative Research Grant (AP/3/2012/CG/29) of the University of Colombo. en_US
dc.language.iso en en_US
dc.publisher Proceedings of the 13th Agricultural Research Symposium, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka. en_US
dc.subject Carica papaya en_US
dc.subject Immunostimulatory Activity en_US
dc.subject Mature Leaf Concentrate en_US
dc.subject Immunomodulation en_US
dc.title Immunostimulatory activity of Sri Lankan wild type Carica papaya L. mature leaf concentrate in a rat model. en_US
dc.type Article en_US


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