Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka

Wickramarachchi, Thilan; Premaratne, Prasad H.; Perera, K. L. R. Lakshman; Bandara, Sumith; Thomas, Alan W.; Handunnetti, Shiroma M.; Udagama-Randeniya, Preethi V.

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dc.contributor.author	Wickramarachchi, Thilan
dc.contributor.author	Premaratne, Prasad H.
dc.contributor.author	Perera, K. L. R. Lakshman
dc.contributor.author	Bandara, Sumith
dc.contributor.author	Thomas, Alan W.
dc.contributor.author	Handunnetti, Shiroma M.
dc.contributor.author	Udagama-Randeniya, Preethi V.
dc.date.accessioned	2021-06-05T10:15:12Z
dc.date.available	2021-06-05T10:15:12Z
dc.date.issued	2005
dc.identifier.citation	27	en_US
dc.identifier.other	doi:10.1128/IAI.74.1.798–801.2006
dc.identifier.uri	http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5235
dc.description.abstract	Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity.	en_US
dc.description.sponsorship	This work was supported by the National Science Foundation, Sri Lanka (grant no. SIDA/99/BT/01), and the International Foundation for Science, Sweden (grant no. W3008-1).	en_US
dc.language.iso	en	en_US
dc.publisher	INFECTION AND IMMUNITY	en_US
dc.subject	Plasmodium vivax	en_US
dc.subject	Apical Membrane	en_US
dc.subject	Malaria	en_US
dc.subject	Apical Membrane Antigen 1	en_US
dc.title	Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka	en_US
dc.type	Article	en_US