Department of Basic Sciences & Social Sciences: Recent submissions

Now showing items 21-40 of 50

Structural and functional characterization of a novel molluskan ortholog of TRAF and TNF receptor - associated protein from disk abalone (Haliotis discus discus)

Lee, Y.; Elvitigala, D. A. S.; Whang, I.; Lee, S.; Kim, H.; De Zoysa, M; Oh, C.; Kang, D.H.; Lee, J. (Elsevier, 2014)

Immune signaling cascades have an indispensable role in the host defense of almost all the organisms. Tumor necrosis factor (TNF) signaling is considered as a prominent signaling pathway in vertebrate as well as invertebrate ...
First report on the gastropod proapoptotic AIF3 counterpart from disk abalone (Haliotis discus discus) deciphering its transcriptional modulation by induced pathogenic stress

Elvitigala, D. A. S..; Jayasooriya, R. G. P. T; Whang, I; Lee, J. (Elsevier, 2015)

Apoptosis inducing factor (AIF) is a flavoprotein that is involved in oxidative phosphorylation and induces apoptosis in eukaryotic cells. There are three isozymes of AIF that have been identified to date, designated as ...
Identification of a C- reactive protein like homologue from black rockfish (Sebastes Schlegelii) evidencing its potent anti-microbial properties at molecular level

Elvitigala, D. A. S.; Wan, Q.; Kim, H. C.; Lee, J. (Elsevier, 2015)

Pentraxins are a family of evolutionary conserved proteins that contains two main members, namely creactive proteins (CRPs) and serum amyloid P (SAP), which are involved in acute phase responses in animals. In this study, ...
The Molecular Profiling of a Teleostan Counterpart of Follistatin, Identified from Rock Bream Oplegnathus fasciatus which Reveals its Transcriptional Responses against Pathogenic Stress

Herath, H. M. L. P. B.; Priyathilaka, T. T.; Elvitigala, D. A. S.; Umasuthan, N.; Lee, J. (2015)

The follistatin (FST) gene encodes a monomeric glycoprotein that plays a role in binding and inhibiting the functions of members of the transforming growth factor (TGF)-β superfamily. Thus, FST facilitates a wide variety ...
Molecular cloning, expression and functional characterization of a teleostan cytokin-induced apoptosis inhibitor from rock bream (Oplegnathus fasciatus)

Elvitigala, D. A. S.; Premachandra, H. K. A.; Whang, I; Yeo, S. Y.; Choi, C. Y.; Noh, J. K.,; Lee, J. (Elsevier, 2015)

Apoptosis plays a key role in the physiology of multicellular organisms and is regulated by different promoting and inhibitory mechanisms. Cytokine-induced apoptotic inhibitor (CIAPI) was recently identified as a key ...
Molecular characterization of two immunity - related acute- phase proteins : Haptoglobin and serum amyloid A from black rockfish (Sebastes schlegeli)

Jayasinghe, J. D. H. E.; Elvitigala, D. A. S.; Whang, I.; Nam, B. H.; Lee, J. (Elsevier, 2015)

Haptoglobin (Hp) and serum amyloid A (SAA) are two vital proteins involved in inflammatory reactions and are classified as acute-phase proteins. They are released from hepatocytes under inflammatory conditions to protect ...
Identification of a myeloperoxidase - like ortholog from rock bream (Oplegnathus fasciatus), deciphering its transcriptional responses to included pathogen stress

Elvitigala, D. A. S.; Whang, I.; Nam, B. H.; Park, H. C.; Lee, J. (Elsevier, 2015)

Myeloperoxidases (MPOs) are heme-linked oxidative stress-generating enzymes found abundantly in azurophilic granules of polymorphonuclear neutrophils. Mature MPOs act as potent antimicrobial agents by producing hypohalous ...
A teleostan homolog of catalase from black rockfish (Sebastes schelegelii) : Insights into functional roles in host antioxidant defense and expressional responses to septic conditions

Elvitigala, D. A. S.; Priyathilaka, T. T.; Whang, I.; Nam, B. H.; Lee, J (Elsevier, 2015)

Antioxidative defense renders a significant protection against environmental stress in organisms and maintains the correct redox balance in cells, thereby supporting proper immune function. Catalase is an indispensable ...
Molecular profiling and functional insights of rock bream (Oplegnathus fasciatus) thioredoxin reductase 3 - like molecule : investigation of its transcriptional modulation in response to live pathogen stress

Elvitigala, D. A. S.; Whang, I.; Lee, J. (Elsevier, 2015)

The thioredoxin (Trx) system plays a significant role in cellular antioxidative defense by dismutating the surpluses of reactive oxygen species. Thus, the role of thioredoxin reductase (TrxR) cannot be ignored, owing to ...
Molecular delineation of a caspase 1 homolog from black rockfish (sebastes schlegelii) and its transcriptional regulation in response to pathogenic stress

Elvitigala, D. A. S.; Whang, I.; Jung, H. B.; Lim, B. S.; Nam, B. H.; Lee, J. (Elsevier, 2015)

Caspase 10 is an initiator caspase in death cascades of death receptor mediated apoptotic signaling. We identified and molecularly characterized a novel homolog of caspase 10 from black rockfish (Sebastes schlegelii) and ...
Molecular and functional characterization of caspase - 8 from the big-belly seahorse (Hippocampus abdominalis)

Oh, M.; Elvitigala, D. A. S.; Bathige, S. D. N. K; Lee, S.; Kim, M. J.; Lee, J. (Elsevier, 2016)

Apoptosis is a physiological process that can also participate in host immune defense mechanisms, including tumor growth suppression along with homeostasis and maturation of immune cells. Caspases are known to be involved ...
Characterization of a 1 - cysteine peroxiredoxin from big-belly seahorse (Hippocampus abdominalis) ; insights into host antioxidant defense, molecular profiling and its expressional response to septic conditions

Godahewa, G. I.; Perera, N. C. N.; Elvitigala, D. A. S.; Jayasooriya, R. G. P. T.; Kim, G. Y.; Lee, J. (Elsevier, 2016)

1-cysteine peroxiredoxin (Prx6) is an antioxidant enzyme that protects cells by detoxifying multiple peroxide species. This study aimed to describe molecular features, functional assessments and potential immune responses ...
Identification and molecular characterization of peroxiredoxin 6 from japanese eel (Anguilla japonica) revealing its potent antioxidant properties and putative immune relevancy

Priyathilaka, T.T.; Kim, Y; Udayantha, H. M. V; Lee, S.; Herath, H. M. L. P. B.; Lakmal, H. C; Elvitigala, D.A.S.; Umasuthan, N.; Godahewa, G.I.; Kang, S.I.; Jeong, H.B; Kim, S,K.; Kim, D.J (Elsevier, 2016)

Peroxiredoxins (Prdx) are thiol specific antioxidant enzymes that play a pivotal role in cellular oxidative stress by reducing toxic peroxide compounds into nontoxic products. In this study, we identified and characterized ...
First comparative characterization of three distinct ferritin subunits from a teleost : Evidence for immune-responsive mRNA expression and iron depriving activity of seahorse (Hippocampus abdominalis) ferritins

Oh, M.; Umasuthan, N.; Elvitigala, D. A. S; Wan, Q.; Jo, E.; Noh, G.E.; Shin, S.; Rho, S.; Lee, J. (Elsevier, 2016)

Ferritins play an indispensable role in iron homeostasis through their iron-withholding function in living beings. In the current study, cDNA sequences of three distinct ferritin subunits, including a ferritin H, a ferritin ...
Molecular characterization and comparative expression analysis of two teleostean pro-inflammatory cytokines, IL - 1β and IL-8, from sebastes schlegeli

Herath, H. M. L. P. B; Elvitigala, D. A. S; Godahewa, G.L; Umasuthan, N; Whang, I.; Noh, J.K.; Lee, J (Elsevier, 2016)

Interleukin 1β (IL-1β) and interleukin 8 (IL-8) are two major pro-inflammatory cytokines which play a central role in initiation of inflammatory responses against bacterial- and viral-infections. IL-1β is a member of the ...
Identification and molecular profiling of DC - SIGN - like from big belly seahorse (Hippocampus abdominalis) inferring its potential relevancy in host immunity

Jo, E.; Elvitigala, D. A. S; Wan, Q.; Oh, M.; Oh, C.; Lee, J. (Elsevier, 2017)

Dendritic-cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) is a C-type lectin that functions as a pattern recognition receptor by recognizing pathogen-associated molecular patterns (PAMPs). It is also involved in ...
Molecular Characterization of a bactericidal permeability - increasing protein / ilpopolysaccharide - binding protein from black rockfish (sebastes schlegelii) : Deciphering its putative antibacterial role

Lee, S.; Elvitigala, D. A. S; Lee, S.; Kim, H. C; Park, H. C; Lee, J. (Elsevier, 2017)

Bactericidal permeability-increasing protein (BPI)/lipopolysaccharide (LPS) binding proteins (LBPs) are well-known proteins that play an indispensable role in host antimicrobial defense. Herein, we report a homolog of ...
Molecular Cloning, Over-expression and Enzymatic Characterization of an Endo-acting β-1,3-glucanase from Marine Bacterium Mesoflavibacter zeaxanthinifaciens S86 in Escherichia coli

Lee, Y; Lee, J. H; Shim, W. B; Elvitigala, D. A. S.,; De Zoysa, M; Lee, S. J; Kang, H.D; Oh, C (2014)

Glucanases are involved in degradation of glucans. Here, we report a new endo-β-1,3-glucanase Mzl86 identified in Mesoflavibacter zeaxanthinifaciens S86. The deduced amino-acid sequence of Mzl86 showed highest similarity ...
The Molecular Profiling of a Teleostan Counterpart of Follistatin, Identified from Rock Bream Oplegnathus fasciatus which Reveals its Transcriptional Responses against Pathogenic Stress

Herath, H. M. L. P. B; Priyathilaka, T. T.; Elvitigala, D. A. S; Umasuthan, N; Lee, J (2015)

The follistatin (FST) gene encodes a monomeric glycoprotein that plays a role in binding and inhibiting the functions of members of the transforming growth factor (TGF)-β superfamily. Thus, FST facilitates a wide variety ...
Molecular proﬁle and expressional modulation of a Toll like receptor-1 homolog from rock bream (Oplegnathus fasciatus)

Elvitigala, D. A. S; Premachandra, H. K. A; Yeo, S. Y; Choi, C. Y; Whang, I; Lee, J. (2015)

Toll-like receptors (TLRs) are well-described pattern recognition receptors that recognize different pathogen-associated molecular patterns (PAMPs) to activate innate immune responses. TLR1 forms a heterodimer with TLR2 ...

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