Department of Basic Sciences & Social Sciences: Recent submissions

Now showing items 1-20 of 50

Energy drinks consumption-prevalence, associations, awareness on health risks and its potential relationship with subsequent substance use among residential students in University of Colombo

De Silva, D.K.M.; Dissanayake, D.M.B.M.; Thilakarathna, P.K.I.S.; Kumara, G.L.S.; Shamen, U.J.L.; Dharmasiri, W.D.D.S.; Rozni, A.G.M.; Minna, N.L.F.; Ubhayawardhana, D.L.N.L.; Elvitigala, D.A.S. (University of Colombo, 2023)

Introduction: The global Energy Drink (ED) market is continuously expanding, and the ED market is more often oriented toward youth and young adults. This has raised concerns among healthcare professionals that young ...
Hypocalcemia in Dengue Patients: A Single Center Observational Study in Central Sri Lanka

Warnasooriya, W.M.S.N.; Jayasinghe, S.; Amarasinghe, T.S.; Rajapakse, R.P.V.J.; Kularatne, S.A.M. (2022)

Introduction: Dengue is known to be fatal due to the limited evidence of pathogenesis and specific treatment options. Serum calcium is very important in cardiac functions, haemostasis and immunopathogenesis. Objective: ...
Effectiveness of Methylprednisolone in the Treatment of Dengue Fever: An Observational Study

Alwis, K.; Rajapaksha, M.B.D.T.; Amarasinghe, T.S.; Warnasooriya, W.M.S.N.; Ralapanawa, D.M.P.U.K.; Kularatne, S.A.M. (2022)

Introduction: Dengue infection can cause intense immune activation causing cytokine overproduction and Cytokine Storm Syndrome (CSS). Steroids are known to have an action on CSS. Abolition of overproduction of Cytokines ...
Isolation of Zerumbone, the Potent Bioactive Compound, from Sri Lankan Zingiber Zerumbet (L)

Weeratunge, H.D.; De Silva, E.D.; Premakumara, G.A.S. (2022)

Introduction: Zingiber zerumbet (L), a member of the family Zingiberaceae, known as “Wal-inguru” in Sri Lanka is a medicinal herb distributed in Sri Lanka, Bangladesh, India, Malaysia and Nepal. This plant is used to ...
Consumer Attitude towards Genetically Modified Foods of a Selected Community in A Grama Niladhari Division of Kalutara District, Sri Lanka

Wickramasinghe, W.T.R.; Dhananjani, M.A.; Pathirage, D.C.; Ransika, E.A.M.; Yuwanthika, B.A.S.; Kulathunga, H.; Ubhayawardana, D.L.N.L. (2022)

Introduction: Genetically modified foods (GM) consist of plants and animals which has experienced gene manipulation. Most of the time, consumers have no idea that their food has been modified. The reported negative results ...
Undergraduate Nursing Students’ Perception and Barriers Towards Online Learning in a State University, Sri Lanka: A Quantitative Study

Rahinduwa, H.R.B.K.; Amarasinghe, T.S.; Wijesinghe, N.T.; Dasanayake, D.R.T.S.; Samarasekara, S.D.B.P.P.; Rathnayake, A.U. (2021)

Introduction: Nursing is a skill-based discipline. The effectiveness of online learning methodologies has not been well examined prior to adoption at many institutions. The sudden transition of physical classes into ...
Anti-Covid 19 Drug Candidates from Sri Lankan Natural Products: In-Silico Approach to Identify Inhibitors of SARS COV 2

Abdulla, S.M.; Premakumara, G.A.S.; Ranasinghe, P.; Udawatte, C. (2021)

Introduction: The development of potent antiviral drugs against COVID-19 is of utmost importance. In this context, computational pharmacology may play a lead role. This study aimed on in-silico screening of Sri Lankan ...
Prevalence and Factors Associated with Masked and White Coat Hypertension Among the Residents in Sri Jayewardenepura Kotte Municipality Area – A Cross Sectional Study

Kariyawasam, K.H.A.Y.; Somathilake, B.G.G.K.; Daluwakgoda, V.; Kamaladasa, A.I.; De Silva, H.R.T.; Jeewandara, J.M.K.C.; Elvitigala, D.A.S. (2021)

Introduction: Masked hypertension (MH) and white coat hypertension (WCH) are clinically misdiagnosed as Sustained Normotension (SN) and Sustained Hypertension (SH), respectively, only relying on clinical BP values of the ...
Genomic characterization and expression profiles upon bacterial infection of a novel cystatin B homologue from disk abalone ( Haliotis discus discus)

Premachandra, H. K. A.; Wan, Q.; Elvitigala, D. A. S; De Zoysa, M.; Choi, C. Y.; Whang, I.; Lee, J. (Elsevier, 2012)

Cystatins are a large family of cysteine proteinase inhibitors which are involved in diverse biological and pathological processes. In the present study, we identified a gene related to cystatin superfamily, AbCyt B, from ...
Ferritin H-like subunit from Manila clam (Ruditapes philippinarum) : Molecular insights as a potent player in host antibacterial defense

Kim, H.; Elvitigala, D. A. S.; Lee, Y.; Lee, S.; Whang, I.; Lee, J. (Elsevier, 2012)

Ferritins are iron chelating proteins, which involve in iron metabolism and sequestration, contributing to the iron homeostasis in living organisms. In the present study, one ferritin subunit which was identified as ...
Caspase 3 from rock bream (Oplegnathus fasciatus) : Genomic characterization and transcriptional profiling upon bacterial and viral inductions

Elvitigala, D. A. S.; Whang, I.; Premachandra, H. K. A.; Umasuthan, N.; Oh, M. J.; Jung, S. J; Yeo, S.Y.; Lim, B.S.; Lee, J.H.; Park, H.C.; Lee, J. (Elsevier, 2012)

Caspase 3 is a prominent mediator of apoptosis and participates in the cell death signaling cascade. In this study, caspase 3 was identified (Rbcasp3) and characterized from rock bream (Oplegnathus fasciatus). The ...
Molecular insights of the first gastropod TLR counterpart form disk abalone (Haliotis discus discus), revealing its transcriptional modulation under pathogenic stress

Elvitigala, D. A. S.; Premachandra, H. K. A.; Whang, I.; Nam, B. H.; Lee, J. (Elsevier, 2013)

Toll-like receptors (TLRs) are well-characterized pattern recognition receptors of innate immunity, known to induce immune responses against the pathogens by interacting with evolutionarily conserved pathogen-associated ...
Genomic structure and immunological response of an STAT4 family member from rock bream (Oplegnathus fasciatus)

Premachandra, H. K. A.; Elvitigala, D. A. S.; Bathige, S. D. N. K.; Whang, I; Lee, Y.; De Zoysa, M.; Lee, J. (Elsevier, 2013)

The Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a critical role in host defense against viral and bacterial infections. STAT proteins are a group of transcription ...
A teleostean counterpart of ferritin M subunit from rock bream (Oplegnathus fasciatus) : An active constituent in iron chelation and DNA protection against oxidative damage, with a modulated expression upon pathogen stress

Elvitigala, D. A. S.; Premachandra, H. K. A.; Whang, I.; Oh, M. J.; Jung, S. J.; Park, C. J.; Lee, J (Elsevier, 2013)

Ferritins are biological iron chelators that can sequestrate excess iron to maintain iron homeostasis in the body. Ferritins basically consist of 2 types of subunits, designated as H and L. However, another new subunit, ...
Marine teleost ortholog of catalase from rock bream (Oplegnathus fasciatus): Moleculr perspectives from genomic organization to enzymatic behavior with respect to its potent antioxidant properties

Elvitigala, D. A. S.; Premachandra, H. K. A.; Whang, I.; Priyathilaka, T. T.; Kim, E.; Lim, B. S.; Jung, H.B.; Yeo, S. Y.; Park, H. C.; Lee, J. (Elsevier, 2013)

Catalases are well known antioxidant enzymes that can mainly dismutate hydrogen peroxide into water and oxygen in order to prevent oxidative stress. The complete genomic DNA (gDNA) sequence of the catalase gene from rock ...
Expression profile o cystain B ortholog from manila clam (Reditapes philippinarum) in host pathology with respect to its structural and functional properties

Premachandra, H. K. A.; Elvitigala, D. A. S.; Whang, I.; Kim, E; De Zoysa, M.; Lim, B. S; Yeo, S.Y.; Kim, S.; Park, H.C.; Park, M.A.; Lee, J. (Elsevier, 2013)

Cystatins are a well-characterized group of cysteine protease inhibitors, which play crucial roles in physiology and immunity. In the present study, an invertebrate ortholog of cystatin B was identified in Manila clam ...
Identification of a novel molluscan short-type peptidoglycan recognition protein in disk abalone (Haliotis discus discus) involved in host antibacterial defense

Premachandra, H. K. A.; Elvitigala, D. A. S.; Whang, I.; Lee, J. (Elsevier, 2014)

Peptidoglycan recognition proteins (PGRPs) are a widely studied group of pattern recognition receptors found in invertebrate as well as vertebrate lineages, and are involved in bacterial pathogen sensing. However, in ...
Future Prospects and Health Benefits of Functional Ingredients from Marine Bio-resources: A review

Samarakoon, K. W.; Elvitigala, D. A. S.; Lakmal, H. H.; Kim, Y. M.; Jeon, Y. J. (2014)

The marine ecosystem represents a vast and dynamic array of bio-resources attributed with its huge diversity and considered as potential untapped reservoirs for the development of functional foods for future health markets. ...
Molecular profile and functional characterization of the ferritin H subunit from rock bream (Oplegnathus fasciatus), revealing its putative role in host antioxidant and immune defense

Elvitigala, D. A. S.; Priyathilaka, T. T.; Lim, B. S.; Whang, I.; Yeo, S. Y.; Choi, C. Y; Lee, J. (Elsevier, 2014)

Ferritins are iron binding proteins made out of 24 subunits, involved in iron homeostasis and metabolism in cellular environments. Here, we sought to identify and functionally characterize a one type of subunits of ...
Molecular characterization and transcriptional analysis of non-mammalian type toll like receptor (TLR21) from rock bream (Oplegnathus faciatus)

Priyathilaka, T. T.; Elvitigala, D. A. S.; Whang, I.; Lim, B. S.; Jeong, H. B.; Yeo, S.Y.; Choi, C.Y; Lee, J. (Elsevier, 2014)

Toll-like receptors (TLRs) are a large family of pattern recognition receptors, which are involved in triggering host immune responses against various pathogens by detecting their evolutionarily conserved pathogen associated ...

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