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Now showing items 1-20 of 50

Anti-Covid 19 Drug Candidates from Sri Lankan Natural Products: In-Silico Approach to Identify Inhibitors of SARS COV 2

Abdulla, S.M.; Premakumara, G.A.S.; Ranasinghe, P.; Udawatte, C. (2021)

Introduction: The development of potent antiviral drugs against COVID-19 is of utmost importance. In this context, computational pharmacology may play a lead role. This study aimed on in-silico screening of Sri Lankan ...
Association Between Selected Human Leukocyte Antigen Alleles and Helicobacter pylori Infection Among Dyspeptic Patients

Arachchi, P. S; Gunasekara, C. P; Weerasekera, M. M; Ubhayawardana, N. L; Weerasekera, D; Samarasinghe, K; Seneviratna, B; Fernando, N (2016)

Background: Helicobacter pylori has been identified as a group I carcinogenic bacterium that infects the gastric mucosa leading to gastritis, peptic ulcer disease, lymphoma, and gastric cancer. Pathogenesis of H. pylori ...
Caspase 3 from rock bream (Oplegnathus fasciatus) : Genomic characterization and transcriptional profiling upon bacterial and viral inductions

Elvitigala, D. A. S.; Whang, I.; Premachandra, H. K. A.; Umasuthan, N.; Oh, M. J.; Jung, S. J; Yeo, S.Y.; Lim, B.S.; Lee, J.H.; Park, H.C.; Lee, J. (Elsevier, 2012)

Caspase 3 is a prominent mediator of apoptosis and participates in the cell death signaling cascade. In this study, caspase 3 was identified (Rbcasp3) and characterized from rock bream (Oplegnathus fasciatus). The ...
Characterization of a 1 - cysteine peroxiredoxin from big-belly seahorse (Hippocampus abdominalis) ; insights into host antioxidant defense, molecular profiling and its expressional response to septic conditions

Godahewa, G. I.; Perera, N. C. N.; Elvitigala, D. A. S.; Jayasooriya, R. G. P. T.; Kim, G. Y.; Lee, J. (Elsevier, 2016)

1-cysteine peroxiredoxin (Prx6) is an antioxidant enzyme that protects cells by detoxifying multiple peroxide species. This study aimed to describe molecular features, functional assessments and potential immune responses ...
Characterization of a nucleotide-oligomerization domain (NOD) like receptor C5 (NLRC5) subfamily member from black rockﬁsh (Sebastes schlegelii), portraying its transcriptional responses against immune stimulants

Elvitigala, D. A. S; Thulasitha, W. S; Lee, J. (2016)

Nucleotide-oligomerization domain like receptors (NLRs) are recently identiﬁed group of pattern recognition receptors which involve in sensing broad range of pathogen associated molecular patterns or damage associated ...
Circulating Micro RNA 21 Levels in Gastric Cancer Patients in Sri Lanka and Role of Helicobacter pylori as a Risk for Development of Gastric Cancer

Ubhayawardana, D. L. N. L; Nisansala, G. G. T; Arachchi, P. S; Rajakaruna, K; Wanigasekera, D. K; Gunasekera, D; Gunasekara, T. D. C. P. (2020)

Background: Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. This study was conducted to evaluate the usefulness of miR-21 as a less invasive screening and ...
Cloning and characterisation of an endosperm specific glutelin B1 promoter from Sri Lankan rice (Oryza sativa L. ssp. indica) variety Bg 250

Kajendran, K; Chandrasekharan, N. V; Hettiarachchi, C. M; Nanayakkara, A. K; Elvitigala, D. A. S; Wijesundera, W. S. S. (2019)

Glutelins are the primary source of energy storage in the endosperm of rice grains. Among the glutelin promoters, Glutelin B-1 (GluB-1) is widely studied and used in transgenic rice plants to express recombinant proteins ...
Consumer Attitude towards Genetically Modified Foods of a Selected Community in A Grama Niladhari Division of Kalutara District, Sri Lanka

Wickramasinghe, W.T.R.; Dhananjani, M.A.; Pathirage, D.C.; Ransika, E.A.M.; Yuwanthika, B.A.S.; Kulathunga, H.; Ubhayawardana, D.L.N.L. (2022)

Introduction: Genetically modified foods (GM) consist of plants and animals which has experienced gene manipulation. Most of the time, consumers have no idea that their food has been modified. The reported negative results ...
Direct Microscopy of Stool Samples for Determining the Prevalence of Soil-Transmitted Helminthic Infections among Primary School Children in Kaduwela MOH Area of Sri Lanka following Floods in 2016

Ubhayawardana, D. L. N. L; Gammana Liyanage, I; Herath, H. M. J. C. B; Amarasekera, U; Dissanayake, T; de Silva, S; Ekanayake, S (2018)

A descriptive cross-sectional school based study was carried out to investigate the prevalence of soil-transmitted intestinal helminthsandtheassociatedfactorsamongschoolchildreninKaduwelaMedicalOfficerofHealth(MOH)areaintheColombo ...
Effectiveness of Methylprednisolone in the Treatment of Dengue Fever: An Observational Study

Alwis, K.; Rajapaksha, M.B.D.T.; Amarasinghe, T.S.; Warnasooriya, W.M.S.N.; Ralapanawa, D.M.P.U.K.; Kularatne, S.A.M. (2022)

Introduction: Dengue infection can cause intense immune activation causing cytokine overproduction and Cytokine Storm Syndrome (CSS). Steroids are known to have an action on CSS. Abolition of overproduction of Cytokines ...
Energy drinks consumption-prevalence, associations, awareness on health risks and its potential relationship with subsequent substance use among residential students in University of Colombo

De Silva, D.K.M.; Dissanayake, D.M.B.M.; Thilakarathna, P.K.I.S.; Kumara, G.L.S.; Shamen, U.J.L.; Dharmasiri, W.D.D.S.; Rozni, A.G.M.; Minna, N.L.F.; Ubhayawardhana, D.L.N.L.; Elvitigala, D.A.S. (University of Colombo, 2023)

Introduction: The global Energy Drink (ED) market is continuously expanding, and the ED market is more often oriented toward youth and young adults. This has raised concerns among healthcare professionals that young ...
Essentials in clinical biochemistry for health care delivery Q & A approach

Elvitigala, D. A. S. (Lap Lambert Academic Publishing, 2020)
Expression profile o cystain B ortholog from manila clam (Reditapes philippinarum) in host pathology with respect to its structural and functional properties

Premachandra, H. K. A.; Elvitigala, D. A. S.; Whang, I.; Kim, E; De Zoysa, M.; Lim, B. S; Yeo, S.Y.; Kim, S.; Park, H.C.; Park, M.A.; Lee, J. (Elsevier, 2013)

Cystatins are a well-characterized group of cysteine protease inhibitors, which play crucial roles in physiology and immunity. In the present study, an invertebrate ortholog of cystatin B was identified in Manila clam ...
Ferritin H-like subunit from Manila clam (Ruditapes philippinarum) : Molecular insights as a potent player in host antibacterial defense

Kim, H.; Elvitigala, D. A. S.; Lee, Y.; Lee, S.; Whang, I.; Lee, J. (Elsevier, 2012)

Ferritins are iron chelating proteins, which involve in iron metabolism and sequestration, contributing to the iron homeostasis in living organisms. In the present study, one ferritin subunit which was identified as ...
First comparative characterization of three distinct ferritin subunits from a teleost : Evidence for immune-responsive mRNA expression and iron depriving activity of seahorse (Hippocampus abdominalis) ferritins

Oh, M.; Umasuthan, N.; Elvitigala, D. A. S; Wan, Q.; Jo, E.; Noh, G.E.; Shin, S.; Rho, S.; Lee, J. (Elsevier, 2016)

Ferritins play an indispensable role in iron homeostasis through their iron-withholding function in living beings. In the current study, cDNA sequences of three distinct ferritin subunits, including a ferritin H, a ferritin ...
First report on the gastropod proapoptotic AIF3 counterpart from disk abalone (Haliotis discus discus) deciphering its transcriptional modulation by induced pathogenic stress

Elvitigala, D. A. S..; Jayasooriya, R. G. P. T; Whang, I; Lee, J. (Elsevier, 2015)

Apoptosis inducing factor (AIF) is a flavoprotein that is involved in oxidative phosphorylation and induces apoptosis in eukaryotic cells. There are three isozymes of AIF that have been identified to date, designated as ...
Future Prospects and Health Benefits of Functional Ingredients from Marine Bio-resources: A review

Samarakoon, K. W.; Elvitigala, D. A. S.; Lakmal, H. H.; Kim, Y. M.; Jeon, Y. J. (2014)

The marine ecosystem represents a vast and dynamic array of bio-resources attributed with its huge diversity and considered as potential untapped reservoirs for the development of functional foods for future health markets. ...
Genomic characterization and expression profiles upon bacterial infection of a novel cystatin B homologue from disk abalone ( Haliotis discus discus)

Premachandra, H. K. A.; Wan, Q.; Elvitigala, D. A. S; De Zoysa, M.; Choi, C. Y.; Whang, I.; Lee, J. (Elsevier, 2012)

Cystatins are a large family of cysteine proteinase inhibitors which are involved in diverse biological and pathological processes. In the present study, we identified a gene related to cystatin superfamily, AbCyt B, from ...
Genomic structure and immunological response of an STAT4 family member from rock bream (Oplegnathus fasciatus)

Premachandra, H. K. A.; Elvitigala, D. A. S.; Bathige, S. D. N. K.; Whang, I; Lee, Y.; De Zoysa, M.; Lee, J. (Elsevier, 2013)

The Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a critical role in host defense against viral and bacterial infections. STAT proteins are a group of transcription ...
Human stomach microbiota: Effects on health and disease

Ubhayawardana, D. L. N. L; Fernando, S. S. N; Gunasekara, T. D. C. P; Weerasinghe, G. G. Y. H; Weerasekera, M. M; Weerasekara, D. D (2021)

The gut microbiota is a complex ecological community, consisting of trillions of microbes which include bacteria, viruses, fungi and protozoa. The stomach was previously considered as a sterile site uninhabited by microbes ...

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