Articles (local / International): Recent submissions

Now showing items 301-320 of 344

Genetic variation in Sri Lanka

Papiha, S.S.; Mastana, S.S.; Jayasekara, R.W. (Wayne State University Press, 1996)

A population genetic study was designed to analyze genetic composition and population structure of the five main population groups (Sinhalese, Tamils, Moors, Burghers, and Malays) of Sri Lanka. Twentyseven polymorphic and ...
Population genetic study of three VNTR loci (D2S44, D7S22, and D12S11) in five ethnically defined populations of the Indian subcontinent

Jayasekara, R.W.; Papiha, S.S.; Mastana, S.S.; Purandare, C.A.; Chakraborty, R. (Wayne State University Press, 1996)

Using RFLP (restriction fragment length polymorphism) analysis, we have characterized the genotypic variation of three VNTR (variable number of tandem repeat) loci (D2S44, D7S22, and D12S11) with probes YNH24, g3, and ...
Distribution of group specific component (GC) and transferrin (TF) subtypes in populations of Sri Lanka.

Jayasekara, R.W.; Mastana, S.S.; Papiha, S.S. (Springer Nature, 1994)

A random sample of 503 individuals from five endogamous groups of Sri Lanka was studied for the genetic polymorphism of the group specific component (GC) and transferrin (TF) using isoelectric focusing. Both systems showed ...
Skeletal fluorosis with neurological complications

Dissanayake, J.K.; Abeygunasekara, A.; Jayasekara, R.W.; Ranathunga, C.; Ranathunga, N.V. (Sri Lanka Medical Association, 1994)

A case of skeletal fluorosis with spinal cord compression from Kekirawa following consumption of water with high fluoride content for about 20 years is described. The observations of other workers (4,5) and the present ...
Genetic polymorphism of orosomucoid (ORM) in populations of the United Kingdom, Indian subcontinent, and Cambodia

Mastana, S.S.; Jayasekara, R.W.; Fisher, P.; Sokoi, R.J.; Papiha, S.S. (Springer Nature, 1993)

Summary The genetic variation of the human serum orosomucoid (ORM) was investigated by isoelectric focusing (IEF) followed by immunofixation in 15 different populations from East Midlands (United Kingdom), India, Sri Lanka, ...
Screening for Turner syndrome: how useful is the buccal smear test?

De Mel, T.; Jayasekara, R.W.; Warnasooriya, N. (Sri Lanka Medical Association, 1992)

The buccal smear test was used to screen for Turner syndrome in a sample of girls with severe short stature who did not have any other clinical features of that condition. The majority of the girls did not show X chromatin ...
The attitudes of doctors and students towards a genetic service in an Asian country: Sri Lanka

Jayasekara, R.W. (Wiley, 1989)

A study comparing the views on the acceptance of a genetic service of 302 doctors and 143 final year medical students from Colombo, Sri Lanka, showed both groups have strong positive views on the provision and use of genetic ...
Acceptance of genetic services: A study of physicians in Colombo, Sri Lanka

Jayasekara, R.W.; Kristl, G.B.; Wertelecki, W. (Cambridge University Press, 1988)

Summary A survey of 302 physicians from Colombo, Sri Lanka, reveals a strong overall acceptance of genetic counselling, prenatal diagnosis of genetic disorders and therapeutic abortion. Demographic and experiential factors, ...
Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka

Dissanayake, V.H.W.; Wettasinghe, T.K.; Jayasekara, R.W. (Oxford University Press, 2010)

background: Many advances have been made in reproductive medicine, yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is ...
A Sri Lankan child with 49,XXXXY syndrome

Dissanayake, V.H.W.; Giles, V.; Bandarage, P. (Wolters Kluwer -- Medknow Publications, 2010)

Pentasomy 49,XXXXY is a rare sex chromosome disorder usually presenting with ambigous genitalia, facial dysmorphism, mental retardation and a combination of cardiac, skeletal and other malformations. The incidence of the ...
Candidate gene study of susceptibility to cutaneous leishmaniasis in Sri Lanka

Samaranayake, T.N.; Fernando, S.D.; Dissanayake, V.H.W. (Wiley, 2010)

objectives To investigate the association between selected single nucleotide polymorphisms (SNPs) in TNF, LTA and SLC11A1 genes and risk of endemic cutaneous leishmaniasis (CL) in Sri Lanka through a case–control disease ...
Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population - implications for association study design and clinical genetic testing services

Dissanayake, V.H.W.; Weerasekara, L.Y.; Gammulla, C.G.; Jayasekara, R.W. (Elsevier, 2009)

We investigated the prevalence of genotypes/alleles of single nucleotide polymorphisms (SNP) and haplotypes defined by them in three genes in which variations are associated with venous thromboembolism in 80 Sinhalese, 80 ...
A study of three candidate genes for pre-eclampsia in a Sinhalese population from Sri Lanka

Dissanayake, V.H.W.; Giles, V.; Jayasekara, R.W.; Senaviratne, H.R.; Kalsheker, N.; Pipkin, F.B.; Morgan, L. (Wiley, 2009)

Aim: The aim of these investigations was to study three candidate genes for pre-eclampsia--epidermal growth factor (EGF), transforming growth factor alpha, and angiotensinogen--in pregnant Sinhalese women from Sri Lanka, ...
Clinical manifestations of cutaneous leishmaniasis in Sri Lanka - Possible evidence for genetic susceptibility among the Sinhalese

Samaranayake, T.N.; Dissanayake, V.H.W.; Fernando, S.D. (Taylor & Francis, 2008)

Human cutaneous leishmaniasis (CL) caused by Leishmania donovani, a pathogen more usually associated with visceral leishmaniasis, is now endemic in Sri Lanka. This report details the characteristics of 200 patients with ...
Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans

Dissanayake, V.H.W.; Tower, C.; Broderic, A.; Stocker, L.J.; Senaviratne, H.R.; Jayasekara, R.W.; Kalsheker, N.; Pipkin, F.B.; Morgan, L. (Oxford University Press, 2007)

Birthweight predicts health later in life and is influenced by inherited factors. We investigated the association of the c.61G > A, and c.2566G > A polymorphisms in the epidermal growth factor (EGF) gene [GenBank NM_001963] ...
Morbidity and mortality associated with pre-eclampsia at two tertiary care hospitals in Sri Lanka

Dissanayake, V.H.W.; Samarasinghe, H.D.; Morgan, L.; Jayasekara, R.W.; Senaviratne, H.R.; Pipkin, F.B. (Wiley, 2007)

Aim: To report the occurrence of morbidity and mortality associated with carefully phenotyped pre-eclampsiain a sample of nulliparous Sinhalese women with strictly deﬁned disease.Methods: A phenotyping database of 180 ...
Contemplating choice: attitudes towards intervening in human reproduction in Sri Lanka

Simpson, B.; Dissanayake, V.H.W.; Jayasekara, R.W. (Taylor & Francis, 2005)

ABSTRACT To date, relatively little is known about the ethical, legal and social responses to recent advances in reproductive and genetic technology outside of Europe and North America. This article reports on a survey ...
The urine protein heat coagulation test - A useful screening test for proteinuria in pregnancy in developing countries: A method validation study

Dissanayake, V.H.W.; Morgon, L.; Pipkin, F.B.; Vathanan, V.; Premaratne, S.; Jayasekara, R.W.; Senaviratne, H.R. (Wiley, 2004)

In many parts of the developing world, the urine protein heat coagulation test is routinely used to screen for proteinuria in pregnancy. The aim of this study was to determine whether > or =1+ on a standardised heat ...
Prenatal testing and pregnancy termination in Sri Lanka: views of medical students and doctors.

Simpson, B.; Dissanayake, V.H.W.; Wickramasinghe, D.; Jayasekara, R.W. (Sri Lanka Medical Association, 2003)

INTRODUCTION: Prenatal diagnosis and pregnancy termination generate complex ethical issues. Surveys conducted in Sri Lanka among doctors and medical students in 1986 supported a change in law in favour of pregnancy termination ...
Establishing a twin register in Sri Lanka

Sumathipala, A.; Fernando, D.J.S.; Siribaddana, S.H.; Abeysingha, M.R.N.; Jayasekara, R.W.; Dissanayake, V.H.W.; De Silva, N. (Macmillan Publisher, 2000)

Nearly all twin registers are based in developed countries and there is no twin register in the developing world. Our objectives were to initiate the process of establishing a nationwide twin register in Sri Lanka by ...

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