Abstract:
Introduction: Tea & coffee consumption could potentially reduce the risk of Stroke &
Parkinson Disease (PD) due to their antioxidant properties. However cigarette smoking is
lead to oxidative stress that may alter the cellular antioxidant defense
system. Method: Study population of 1415 individuals; Stroke:n=772; [Stroke in young
patients «45 yrs) accounted for 16% (124/772), median age of onset 38Yrs; male 12%
(94/124) 37Yrs, female 4% (30/124) 38Yrs; sex ratio of 3.31: 1. Stroke with age~46; male
56% (402/648) & female 34% (246/648) sex ratio of 1.63: 1], PD: n=143; [Male 61%
(87/143), female 39%(56/143), median age of onset 57Yrs] & age matched controls: n=500.
Tea, coffee & cigarette consumption were assessed by a stranded
questionnaire. Results: Stroke with tea consumptlon..aacups/day 63% (490), 2cups/day 23%
434
(177), 1cup/day 9% (70), median age of onset: 62, 59 & 56Yrs respectively. Stroke with
coffee drinkers 36% (278), non-drinkers 64% (494), median age of onset: 61 & 62Yrs
respectively. Stroke with smoking 27% (211), non- smoking 37% (288), median age of
onset: 60 & 61Yrs respectively. PO with tea consumption: ~3cups/day 51 % (73), 2cups/day
36% (51), 1cup/day 12% (17), median age of onset was 57Yrs in all categories. PO with
coffee drinkers 41 % (58), non-drinkers 55% (80), median age of onset: 56 & 57Yrs
respectively. PO with smoking 29% (42), non- smoking 71 % (101) median age of onset:
57Yrs in both categories. Conclusion: Results suggestive of regular consumption of
Ceylon tea is associated with a decreased risk of early onset of Stroke & PO, where coffee
consumption plays a protective role towards early onset of PO, study lay steppingstone on
developing neuroprotective nutraceuticals based on unique regional natural products.
