Abstract:
This review concentrates on different aspects of malaria chemoprophylaxis, namely
drug combinations, resistance, impact of malaria prevention in pregnancy and cost
effectiveness. A MEDLINE search was performed for all articles with the key word
'Malaria' in the title field and 'Prophylaxis' in any field. The search was
restricted to articles published in English within the last decade (1999-2009).
Data sources included review articles published in core clinical journals, cohort
studies, interventional studies, case control studies and cross sectional
analyses. The mechanism of action, trial evidence of efficacy, side effects and
geographical distribution of resistance is discussed for each prophylactic drug
regimen. Impact of prophylaxis in pregnancy and the cost considerations are
discussed under two separate sub topics.
