Department of Zoology: Recent submissions

Now showing items 121-140 of 295

Heavy metal mediated innate immune responses of the Indian green frog, Euphlyctis hexadactylus (Anura: Ranidae): Cellular profiles and associated Th1 skewed cytokine response

Jayawardena, Uthpala A.; Ratnasooriya, Wanigasekara D.; Wickramasinghe, Deepthi D.; Udagama, Preethi V. (Science of The Total Environment, 2016)

Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model ...
Molecular and Scanning Electron Microscopic Proof of Phytoplasma Associated With Areca Palm Yellow Leaf Disease in Sri Lanka

Kanatiwela de Silva, C.; Damayanthi, M.; de Silva, R.; Dickinson, M.; de Silva, N.; Udagama, P. (APS Publications - Plant disease, 2015)

The areca palm, Areca catechu L., of the Arecaceae family, is an important commercial crop in the world, where the drupe, commonly called the areca nut, is mainly used in betel quid chewing in many Asian and Oceanic ...
A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: a case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18

Gunasekera, Suvanthee Kushani; Perera, Kanthi Angela; Fernando, Chandrika; Udagama, Preethi Vidya (Infectious Agents and Cancer, 2015)

Background Oral and pharyngeal cancer (OPC) of multifactorial aetiology is a major health problem globally. Ranking first in all cancers, OPC poses a significant impact on the Sri Lankan male population. As Human ...
Heavy metal mediated immunomodulation of the Indian green frog, Euphlyctis hexadactylus (Anura:Ranidae) in urban wetlands

Priyadarshani, S; Madhushani, W.A.N.; Jayawardena, U.A.; Wickramasinghe, D.D.; Udagama, P.V. (Ecotoxicology and Environmental Safety, 2015)

Impacts of heavy metal toxicity on the immune system of the Indian green frog, Euphlyctis hexadactylus, in Bellanwila Attidiya, an urban wetland polluted with high levels of heavy metals, compared to the reference site in ...
Artemisia vulgaris L. ethanolic leaf extract reverses thrombocytopenia/ thrombocytosis and averts end-stage disease of experimental severe Plasmodium berghei murine malaria

Bamunuarachchi, Gayan S.; Ratnasooriya, Wanigasekara D.; Premakumara, Sirimal; Udagama, Preethi V. (J Vector Borne Disease, 2014)

Background & objectives: Artemisinin isolated from Artemisia annua is the most potent antimalarial against chloroquine resistant Plasmodium falciparum malaria. We previously reported that the ethanolic leaf extract ...
Conserved regions of Plasmodium vivax potential vaccine candidate antigens in Sri Lanka: Conscious in silico analysis of prospective conformational epitope regions

Amarasinghe, Shanika; Kathriarachchi, Hashendra; Udagama, Preethi (Asian Pacific Journal of Tropical Medicine, 2014)

Objective: To map and model conformational B cell epitope regions of highly conserved and protective regions of three merozoitecandidate vaccine proteins of Plasmodium vivax (P. vivax) , i.e. Merozoite Surface Protein-1 ...
Cost-effective diagnosis of male oxidative stress using the nitroblue tetrazolium test: useful application for the developing world

Amarasekara, D. S.; Wijerathna, S.; Fernando, C.; Udagama, P. V. (Andrologia, 2012)

Seminal oxidative stress plays an important role in male factor infertility (MFI), worldwide. A study was thus undertaken for the ﬁrst time to establish seminal reactive oxygen species (ROS) as a clinical marker of MFI in ...
Antimalarial properties of Artemisia vulgaris L. ethanolic leaf extract in a Plasmodium berghei murine malaria model

Bamunuarachchi, Gayan S; Ratnasooriya, Wanigasekara D.; Premakumara, Sirimal; Udagama, Preethi V. (Journal of vector borne diseases ·, 2013)

Background & objectives: Artemisinin isolated from Artemisia annua is the most potent antimalarial drug against chloroquine-resistant Plasmodium falciparum malaria. Artemisia vulgaris, an invasive weed, is the only Artemisia ...
Population genetic structure of the Plasmodium vivax circumsporozoite protein (Pvcsp) in Sri Lanka

Diasa, Sajani; Wickramarachchi, Thilan; Sahabandu, Imeshi; Escalante, Ananias A.; Udagama, Preethi V. (Gene, 2013)

Molecular methods elucidate evolutionary and ecological processes in parasites, where interaction between hosts and parasites enlighten the evolution of parasite lifestyles and host defenses. Population genetics of Plasmodium ...
Ocular and subcutaneous dirofilariasis in a Sri Lankan infant: an environmental hazard caused by dogs and mosquitoes

Senanayake, Manouri P.; Infaq, M. L. M.; Adikaram, S. G. S.; Udagama, P. V. (Paediatrics and International Child Health, 2011)

An 11-month-old infant presented with a subcutaneous nodule in the right cheek which was found by ultrasonography to be a worm. Following treatment with di-ethylcarbamazine, a worm emerged from the left upper eyelid which ...
Bothridium pithonis (Blainville, 1824) from Rock Python (Python morulus) of National Zoological Garden of Sri Lanka

Udugama-Randeniya, P.V.; Fernando, T.S.P.; Kulasena Fernando, H.K.A.V.A (World Journal of Zoology, 2012)

On post mortem examination of a dead adult female Rock python (Python molurus) specimen in the National Zoological garden, Sri Lanka, tapeworms were collected. The morphologic and morphometrics data allowed to conclude ...
Thrombocytosis and Anti-inflammatory Properties, and Toxicological Evaluation of Carica papaya Mature Leaf Concentrate in a Murine Model

Gammulle, Achini; Ratnasooriya, WD; Jayakody, JRAC; Fernando, Charmain; Kanatiwela, Chamini; Udagama, Preethi V. (Online International Journal of Medicinal Plants Research, 2012)

Management of thrombocytopenia is by drugs and blood products, both of which are costly. Conversely, Sri Lankan traditional medicine use mature leaf concentrate of Carica papaya to treat this condition. This claim was ...
A new species of the pseudoscorpion genus Megachernes (Pseudoscorpiones: Chernetidae) associated with a threatened Sri Lankan rainforest rodent, with a review of host associations of Megachernes

Harvey, Mark S.; Ratnaweera, Pamoda B.; Udagama, Preethi V.; Wijesinghe, Mayuri R. (Journal of Natural History, 2012)

Most species of the Old World pseudoscorpion genus Megachernes are associated with mammals, either within their nests or in their pelage, whereas others are found in cave systems, usually in bat guano. The ﬁrst Sri Lankan ...
An investigation of the antimalarial activity of Artemisia vulgaris leaf extract in a rodent malaria model

Kodippili, Kasun; Daya Ratnasooriya, Wanigasekera; Premakumara, Sirimal; Udagama, Preethi V. (International Journal of Green Pharmacy, 2011)

Antimalarial activity of an organic extract of Artemisia vulgaris was evaluated in this study in terms of both antiparasitic and antidisease activities. Antiparasitic activity of the extract at three doses (250, 500, 1000 ...
Evaluation of the genetic diversity of domain II of Plasmodium vivax Apical Membrane Antigen 1 (PvAMA-1) and the ensuing strain-speciﬁc immune responses in patients from Sri Lanka

Dias, Sajani; Somarathna, Maheshika; Manamperi, Aresha; Escalante, Ananias A.; Gunasekera, Anusha M; Udagama, Preethi V. (Vaccine, 2011)

Antigenic polymorphism displayed by malaria parasites is a skewed schema to escape the host immune system. The prevailing genetic diversity at domain II of the Plasmodium vivax Apical Membrane Antigen-1 (Pvama-1DII) was ...
Genetic diversity of Plasmodium vivax Duffy Binding Protein II (PvDBPII) under unstable transmission and low intensity malaria in Sri Lanka

Premaratne, Prasad H.; Aravinda, B. Ramesh; Escalante, Ananias A.; Udagama, Preethi V. (Infection, Genetics and Evolution, 2011)

Elucidating the genetic diversity of the Duffy Binding Protein II (PvDBPII), a leading vaccine candidate for vivax malaria, in different geographical settings is vital. In Sri Lanka malaria transmission is unstable with ...
Genetic diversity and recombination at the C-terminal fragment of the merozoite surface protein-1 of Plasmodium vivax (PvMSP-1) in Sri Lanka

Diasa, Sajani; Longacreb, Shirley; Escalant, Ananias A; Udagama-Randeniya, Preethi V. (Infection, Genetics and Evolution, 2010)

Extensive polymorphism in the genes encoding for surface antigens of Plasmodium falciparum and Plasmodium vivax has been a serious impediment for malaria vaccine development. One such antigen is the merozoite surface ...
Genetic complexity of Plasmodium vivax infections in Sri Lanka, as reflected at the merozoite-surface-protein-3a locus

WICKRAMARACHCHI, T.; PREMARATNE, P. H.; DIAS, S; HANDUNNETTI, S. M.; UDAGAMA-RANDENIYA, P. V. (Annals of Tropical Medicine & Parasitology, 2010)

The presence of genetically different strains of malarial parasites in cases of human malaria is a severe drawback in the successful control of the disease. In Sri Lanka, although this species accounts for 60%–80% of all ...
Parasitic associations of a threatened Sri Lankan rainforest rodent, Mus mayori pococki (Rodentia: Muridae)

Ratnaweera, Pamoda B.; Wijesinghe, Mayuri R.; Udagama-Randeniya, Preethi V. (Parasitic associations of a rainforest rodent, 2010)

Parasitic investigations of the subspecies Mus mayori pococki were carried out in four rainforests that included two man and biosphere reserves and two forest reserves of Sri Lanka from October 2006 to August 2007. Rodents ...
Host speciﬁcity in bat ectoparasites: A natural experiment

Seneviratne, Sampath S.; Fernando, H. Chandrika; Udagama-Randeniya, Preethi V. (International Journal for Parasitology, 2008)

We undertook a ﬁeld study to determine patterns of specialisation of ectoparasites in cave-dwelling bats in Sri Lanka. The hypothesis tested was that strict host speciﬁcity (monoxeny) could evolve through the development ...

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