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Now showing items 1-20 of 295

IMMUNOEPIDEMIOLOGY OF PVRII, A PUTATIVE VACCINE CANDIDATE REPRESENTING PLASMODIUM VIVAX DUFFY BINDING PROTEIN, IN SRI LANKAA

Dias, Sajani; Handunnetti, Shiroma M; Yazdan, Syed S; Chitnis, Chetan E; Randenrya, Preethi V (Lanka.56 th of the Ann. Meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, USA. Supplement to The American Journal of Tropical Medicine and Hygiene 77 (5), Abstract book -pp 55-56, 207)

Study of naturally acquired antibody responses to a potential vaccrne candidate ts rmperatrve to provide insights to vaccine deve opment. Recombinant protein PvRll, a putative vaccine candrdate representrng regron ll ...
A Plant Extract that Prevents Clotting of Mammalian Blood

RATNASOORIYA, W. D.; RANATUNGA, K. W. (1975)

Roots of TerminaUa glabra (Kumbuk—in Sinhala) are used in Ayurvedic medicinal treatment in Sri Lanka, and it has been claimed that a water extract of the roots of T. glabra possesses 'blood anti-coagulant characteristics'. ...
Demonstration of Antigenic Polymorphism in Plasmodium vivax Malaria with a Panel of 30 Monoclonal Antibodies

Udagama, Preethi V.; David, Peter H.; Peiris, J. S. M.; Ariyaratne, Y. G.; Perera, K. L. R. L.; Mendis, Kamini N. (Infection and Immunity, 1987)

A panel of 30 monoclonal antibodies was established against asexual erythrocytic stages of Plasmodium vivax and used to investigate the antigenic composition of the parasite. At least 38 different antigenic polypeptides ...
Immune modulation of parasite transmission in Plasmodium vivax malaria. Anti-gamete antibodies can both block and enhance transmission

Mendi, Kamini N.; Peiris, J.S.M.; Premawansa, Sunil; Udagama, Preethi V.; Munesinghe, Yamuna; Ranawaka, Maya; Carter, Richard; David, Peter H. (Molecular Strategies of Parasitic Invasion, pages 417-426, 1987)

Antibodies directed against Plasmodium vivax gametes can block the development of the parasite in the mosquito vector and interrupt transmission. Usi ng monoclonal antibodies we have defined two components of molecular ...
Plasmadium vivax: Cloning and Expression of a Major Blood-Stage . Surface Antigen

Del Portillo, Hernando A.; Gysin, Jurg; Mattie, Denise M.; Khouri, Elisabeth; Udagama, Preethi V.; Mendis, Kamini N.; David, Peter H (Experimental Parasitology, 1988)

Plasmodium vivax is a highly prevalent malaria pathogen of man; the following report is the first to describe the cloning and expression of a major asexual erythrocytic stage antigen of this species. The screening of a ...
Immunoelectron Microscopy of Schffier's Dots in Plasmodium vivax -Infected Human Erythrocytes

Udagama, Preethi V; Atkinson, Carter T; Peiris, J. S.M.; David, Peter H; Mendis, Kamini N; Aikawa, Masamtchi (American Journal of Pathology, 1988)

Plasmodium vivax induces morphologic alterations in infected host erythrocytes that are visible by light microscopy in Romanovsky-stained blood smears as multiple brick-red dots. These morphologic changes, referred to as ...
Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax Malaria

Malik Peiris, J.S.; Premawansa, Sunil; Ranawaka, Maya B.R; Udagama, Preethi V; Munasinghe, Yamuna D; Nanayakkara, Manjula V; Gamage, C Priyantha; Carter, Richard; David, Peter H; Mendis, Kamini N (The American Society of Tropical Medicine and Hygiene, 1988)

Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human ...
Gastroprotective activity of crude extract of Jania sp (red algae) on ethanol-induced gastric lesions in rats

Ratnasooriya, W.D.; Premakumara, G.A.S.; Tillekeratne, L.M.V. (1990)

Marine-derived bioactive compounds have begun to make significant contributions to biomcdicine, and are likely to continue to do so in future [1]. In this respect, we have initiated a programme of research aimed at ...
Genetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein

Udagama, Preethi V.; Gamage Mendis, Asoka C; David, Peter H.; Peiris, J.S.M.; Perera, K.L.R.L.; Mendis, Kamini N.; Carter, Richard (The American journal of Tropical medicine and hygiene, 1990)

Monoclonal antibodies against variant epitopes of a highly polymorphic protein (PV200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the ...
HYPOTENSIVE ACTIVITY OF CRUDE EXTRACT OF MARINE RED ALGAE, GRACILARIA SP. IN RATS

RATNASOORIYA, W. D.; PREMAKUMARA, G.A.S.; TILLEKERATNE, L.M.V. (1991)

Hypotensive properties of the crude extract of Sri Lankan marine red algae ^ Gracilaria sp. of the family Gracilaracea were investigated on anaesthetized rats using two doses (250 or SOOmg/kg) given intraperitoneally. ...
Cell wall-bound coniferyl Alcohol oxidase associated with lignification in coniofers

Savidge, Rodney A.; Randeniya, Preethi Udagama (Phytochemistry, 1992)

An enzyme utilizing O2 to oxidize coniferyl alcohol into a lignin-like product is described. This enzyme has been found firmly bound to cell walls in developing xylem of Pinus strobus, Abies balsamea, Larix laricina, Picea ...
Exploratory behaviour of male rats treated with a crude extract of Ficus tsiela leaves

Ratnasooriya, W.D.; Premakumara, G.A.S; TilIekeratne, L.M.V. (1992)

In Sri Lanka, herbal treatment is still widely used to suppress aggressive behaviour in elephants (Elephas maximus maximus). According to the mahouts at Pinnawala Elephant Orphanage and the National Zoological Gardens ...
Evidence for coniferyl-alcohol oxidase promotion of Iignification in developing xylem of conifers

Savidge, Rodney A.; Randeniya, Preethi V (Biochemical Society Transactions, 1992)
Gastroprotective effects of an aqueous extract of Cucurbita moschata seeds on ethanol induced gastric lesions in rats

MUNASINGHE, T.P.A.; DE FONSEKA, R.N.; RATNASOORIYA, W.D. (1993)

This study inve.<iligat,ed the polrntial gastroprotective activity of an aqueous extract ofC. moschaia seeds on ral using the lechnic/ne of elhatiot induced gastric lesions. The doses tested were 125, 250, ?75 and 500 ...
Purification of an acidic coniferin-hydrolysing β-glucosidase from developing xylem of Pinus banksiana

Leinhos, Volker; Udagama-Randeniya, Preethi V.; Savidge, Rodney A. (Phytochemistry, 1994)

Two cytosolic, acidic (pI 3.8) glycoproteins (Mr 110 000 and 90 000) from lignifying xylem of Pinus banksiana were electrophoretically isolated and confirmed by combined gas chromatography-mass spectrometry to be capable ...
Studies on the sedative activity of crude extract of root bark of Rauvolfia canescens on rats

Madawala, P.G.; Arambewela, L.S.R.; Premakumara, G.A.S.; Ratnasooria, W.D. (1994)

For centuries, Rauvolfia serpentina Benth. (Apocynaceae) roots have been used as hypnotics and sedatives in neuropsychiatric disorders, in anxiety states and in epilepsy (Srivasta, 1978). A closely related species R. ...
Oral hypoglycaemic effects of Momordica dioica in the rat

Fernandopulle, B.M.R.; Karunanayake, E.H.; Ratnasooriya, W.D. (1994)

Traditionally, the fruit extract of Momordica charantia L. (family: Cucurbitaceae; genus: Momordica) is widely used in Asia and Australasia to treat diabetes meliitus [1]. Another cucurbit, M. foetida, is used for the ...
Analgesic activity of Mormodica dioica fruit extract in rats

Ratnasooriya, W.D.; Fernandopulle, B.M.R.; Manickavasagar, S. (1994)

The fruits of Mormodica dioica Roxb. (Family: cucurbitaceae and referred to as Thumba KarawJla in Sinhalese and Thumbai in Tamil) have been used in traditional medicine in Sri L a n k a as a stomachic, laxative ...
Analgesic activity of Murraya koenigii leaf extract in rats

Ratnasoonya, W.D.; Peiris, L.D.C.; Amarasekera, A.S. (1994)

Some native doctors practising the traditional system of medicine in Sri Lanka recommend leaf extracts of Murraya koenigii Spreng. Sy.st. Veg. (Family Rutaceae; known as karapincha in Sinhala and karuvembu in Tamil) for ...
Anxiolytic effect of Murraya koenigii leaf extract in rats

Ratnasooriya, W . D .; Banduwardene, H.R.; Amarasekera, A.S. (1994)

Use of anxiolytic drugs is increasing. Several classes of such agents are available, benzodiazepines forming the most frequently prescribed group [1], However, most, if not all of these drugs are likely to induce physical ...

Now showing items 1-20 of 295

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