Abstract:
Objective :To observe the effect of yishen juanbi pill on rats' secondary affection of
collagen arthritis,discuss its mechanism.Methods:The models were made by intradermal
injecting chicken type II collagen on the left toes of rats,than each group was given the
corresponding medicine after modeling 2weeks for 14 days,the right hind paw volume of
rats was determined every 4 days.Rats were killed and the right hind paw was taken to make
pathological section,the expressions of NF-κBp 65 subunit and Cox-2 in rats' synovium of
ankle joint were determined by Western blot method.Results:Yishen juanbi pill could inhibit
the tumefaction of digiti pedis of rats with collagen arthritis,there was significant difference
between the Yishen juanbi pill group and model group.Yishen juanbi pill could lower the
levels of NF-κBp 65 subunit and Cox-2 in rats' synovium of ankle joint.Conclusion:Yishen
juanbi pill can inhibit the inflammatory reaction of collagen arthritis rats,inhibiting the
expression of NF-κBp 65 subunit and Cox-2 maybe part of its mechanism.
