Abstract:
BACKGROUND: Inflammatory bowel diseases (IBD) include ulcerative colitis
(UC) and Crohn's disease (CD), which are chronic inflammatory conditions
affecting the gastrointestinal tract. There are only few published data on disease
characteristics of IBD related to South Asia.
OBJECTIVE: To provide the disease characteristics of the IBD patients who
presented to a tertiary care hospital in South Asia.
METHODS: Patients with an established diagnosis of IBD were identified after a
review of their medical records and demographics, and disease characteristics
and indications for surgical treatment were analyzed.
RESULTS: A total of 184 patients (women = 101, 54.9%; UC = 153, 83.2%) were
included. Female preponderance was observed for UC (male/female ratio =1:1.5)
and male for CD (male/female = 2:1). Mean age at the time of diagnosis was 36.3
(range 7-71) years. CD was diagnosed at a significantly younger age than UC
(27.35 ± 10.22 vs. 38.14 ± 13.05 years, p < 0.0001). CD showed a peak age of
onset in the third decade and that for UC was in the fourth decade. The mean
duration of IBD was 8.17 (range 1-28) years. Presenting complaint of the majority
(73.7%) of UC patients was blood and mucous diarrhea and that for CD (77.4%,
24/31) was left-sided abdominal pain. Only 9.5% (n = 18) had at least one extraintestinal
manifestation. Among UC patients, 51.7% (n = 79) had left-sided colitis
and panproctocolitis was found in 18.3% (n = 28). In IBD patients, 14.1% (n = 26)
underwent surgery. Only one patient developed malignancy.
CONCLUSIONS: The majority of UC patients had left-sided colitis. CD compared
to UC was diagnosed at a younger age. However, compared to data reported for
some Western countries, extra-intestinal manifestations and malignancy rates
were lower.
