Abstract:
The gastioprotective acii\il.y of the tVuit extracts
of two cucurbits Momordica cliaraniia and dioica -A as
evaluated by inducing experimental gastric ulcers in the rat.
Both frL'ii extracts (1 inL/lOOg) significantly inhibited the dcvelopmfnt
of absolute ethano! and aspirin induced acute ulcers.
M- dioica H mL/lOOg) also showed significant
proieciioii against inaoi:"icii!Uci.u induced aruic ^lIcI,'i^. .!':J
iifrthemiore, when admini<;tercd daily for 14 days accelerated
the healing of chronic ulcers induced with acetic acid M.
Jwranha did not show significant tlierapeuiic effects --v. ?hc
latter t«'c models. It is concluded that the trait extracts of Mct.
waniia and M. dioica show significant antiulcer effects but
M dio-ra is more potent and therapeutically effective in ali
die .ncdr^h tested. The precise mechanism of action reniains
to be detennined.
