Safety evaluation of Sri Lankan Piper betle leaf extracts in rats

dc.contributor.author	Arambewela, L.S.R.
dc.contributor.author	Arawwawala, L.D.A.M.
dc.contributor.author	Ratnasooriya, W.D.
dc.date.accessioned	2012-03-06T08:22:29Z
dc.date.available	2012-03-06T08:22:29Z
dc.date.issued	2003
dc.identifier.citation	J. Trop. Med. Plants. Vol. 4 No.2 (Dec 2003)	en_US
dc.identifier.uri	http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2156
dc.description.abstract	The aim of this study was to evaluate the safety profile of cold ethanolic extract (CEE) and hot water extract (HWE) of Sri Lankan Piper betle Linn, leaves (Family: Piperaceae).The extracts were orally administrated to rats for 42 consecutive days. These rats were monitored for overt signs of toxicity, stress, morbidity, aversive behaviors or mortality throughout the experiment. Weight gain, food and water intake were determined weekly. On day 1 post treatment, the rats were sacrificed, blood collected and organs were weighed. The results showed that both extracts were well tolerated in terms of % weight gain, food and water intake, morbidity, aversive behaviors, mortality, blood haematology, serum analysis and organ weights except the weight of the spleen, which suggested lymphoproliferative activity
dc.language.iso	en	en_US
dc.title	Safety evaluation of Sri Lankan Piper betle leaf extracts in rats	en_US
dc.type	Journal abstract	en_US