Anti-inflammatory Activity of the Aqueous Leaf Extract of Ixora coccinea

Ralnasooriya, W.D.; Deraniyagala, S.A.; Galhena, G .; Liyanage, S.S.P.; Bathige, S.D.N.K.; Jayakody, J.R.A.C.

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dc.contributor.author	Ralnasooriya, W.D.
dc.contributor.author	Deraniyagala, S.A.
dc.contributor.author	Galhena, G .
dc.contributor.author	Liyanage, S.S.P.
dc.contributor.author	Bathige, S.D.N.K.
dc.contributor.author	Jayakody, J.R.A.C.
dc.date.accessioned	2012-03-06T07:53:56Z
dc.date.available	2012-03-06T07:53:56Z
dc.date.issued	2005
dc.identifier.citation	Pharmaceutical Biology, 2005, Vol. 43, No. 2, pp. 147-152	en_US
dc.identifier.uri	http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2146
dc.description.abstract	The aim of this study was to investigate the antiinflammatory potential of an aqueous leaf extract (ALE) of /xora coccinea (Rubiaceae) in rats after oral administration (500, 1000 and 1500mg/kg). This was done using the carrageenan-induced paw edema (acute inflammatory model) and cotton pellet granuloma tests (chronic inflammatory model). In the former test, A L E signiflcaiitly impaired both early and late phases of the intlammalory response and also the edema maintained between the two phases. In the latter test, it significantly suppressed granuloma formation (only highest dose tested). Collectively, these data show promising anii-inflanimatory activity against both acute and chronic inflammation. A L E showed strong antihistamine i^nd antioxidant activities that can account for its -uni-inflammatory potential. In addition, inhibition of prostaglandins and bradykinins may play a role
dc.language.iso	en	en_US
dc.title	Anti-inflammatory Activity of the Aqueous Leaf Extract of Ixora coccinea	en_US
dc.type	Journal abstract	en_US