Antidiarrhoeal activity of decoction of Scoparia dulcis in rats

dc.contributor.author	Ratnasooriya, W.D.
dc.contributor.author	Galhena, G.
dc.contributor.author	Liyanage, S.S.P.
dc.contributor.author	Jayakody, J.R.A.C.
dc.contributor.author	Hettiarachchi, A.D.I.
dc.contributor.author	Ediriweera, E.R.S.S.
dc.date.accessioned	2012-03-06T05:23:57Z
dc.date.available	2012-03-06T05:23:57Z
dc.date.issued	2005
dc.identifier.citation	Vidyodaya J. of Sci. (2005) Vol. 12. pp 57-63	en_US
dc.identifier.uri	http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2138
dc.description.abstract	The aim of this study was to investigate the antidiarrhoeal potential of a decoction (D) made from Scoparia dulcis Linn (Family: Scrophulariaceae), as indicated by traditional practitioners in Sri Lanka, using the caster oil-induced diarrhoeal rat model. Different doses of D (500,1500,3000 mg/kg) were orally administrated and antidiarrhoeal activity monitored over a 6 h period. The D induced a significant (P<0.05) and dose- dependent antidiarrhoeal effect from Ih post treatment. This antidiarrhoeal action was mediated via an inhibition in intestinal transit due to impairment of intestinal peristalsis, rather than to an increment in intestinal fluid absorption and/or reduction in secretion. The decoction may have a potential in symptomatic reliefofnon-specific acute diarrhoeas.
dc.language.iso	en	en_US
dc.title	Antidiarrhoeal activity of decoction of Scoparia dulcis in rats	en_US
dc.type	Journal abstract	en_US