Department of Clinical Medicine: Recent submissions

Now showing items 181-200 of 200

Current Status of HIV/AIDS in South Asia

Rodrigo, C.; Rajapakse, S. (2009)

BACKGROUND: According to the United Nations Joint Program on HIV/AIDS, 33.2 million adults and children are living with the infection worldwide. Of these, two to three million are estimated to be in South Asia. All ...
Looking at Complicating Non-Biological Issues in Women with HIV

Rodrigo, C.; Rajapakse, S. (2010)

INTRODUCTION: The increasing number of women acquiring Human Immunodeficiency Virus (HIV) has resulted in a 'feminization' of the epidemic. In this article we are reviewing whether females are disadvantaged in the ...
Symptoms of anxiety and depression in adolescent students; a perspective from Sri Lanka

Rodrigo, C.; Welgama, S.; Gurusinghe, J.; Wijeratne, T.; Jayananda, G.; Rajapakse, S. (2010)

BACKGROUND: Sri Lanka recorded an extraordinary high suicide rate for adolescents aged 15 - 19 in the early 1990s (46.5/100,000). With this in perspective, the Ministry of Health in Sri Lanka recommends school programmes ...
The 'antisocial' person: an insight in to biology, classification and current evidence on treatment

Rodrigo, C.; Rajapakse, S.; Jayananda, G. (2010)

BACKGROUND: This review analyses and summarises the recent advances in understanding the neurobiology of violence and empathy, taxonomical issues on defining personality disorders characterised by disregard for social ...
A retrospective analysis of cannabis use in a cohort of mentally ill patients in Sri Lanka and its implications on policy development

Rodrigo, C.; Welgama, S.; Gunawardana, A.; Maithripala, C.; Jayananda, G.; Rajapakse, S. (2010)

BACKGROUND: Several epidemiological studies have shown that cannabis; the most widely used illegal drug in the world, is associated with schizophrenia spectrum disorders (SSD). AIMS: To assess the characteristics of ...
Venlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease

Rajapakse, S.; Abeynaike, L.; Wickramarathne, T. (2010)

A 43-year-old male patient with idiopathic Parkinson disease, on dopaminergic therapy, was admitted with confusion and agitation, diaphoresis, and hyperkinesia after the commencement of the serotonin-noradrenaline reuptake ...
Developing a clinically relevant classification to predict mortality in severe leptospirosis

Rajapakse, S.; Rodrigo, C.; Haniffa, R. (2010)

BACKGROUND: Severe leptospirosis requires critical care and has a high mortality. We reviewed the literature to identify factors predicting mortality, and such predictors were classified according to the predisposition, ...
Is investigating for carotid artery disease warranted in non-cortical lacunar infarction?

Rajapakse, A.; Rajapakse, S.; Sharma, J.C. (2011)

Carotid intervention in severe carotid stenosis after an anterior circulation ischemic event reduces the risk of further infarcts if the surgery is performed soon after the incident event. At present, there is no ...
The 'hidden' burden of malaria: cognitive impairment following infection

Fernando, S.D.; Rodrigo, C.; Rajapakse, S. (2010)

BACKGROUND: The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial. The objectives of this ...
Drug treatment of scrub typhus

Rajapakse, S.; Rodrigo, C.; Fernando, S.D. (2011)

Scrub typhus is a vector-borne disease caused by the pathogen Orientia tsutsugamushi. We review the published literature for evidence on drug treatment in scrub typhus. Doxycycline has a proven efficacy in several trials ...
Cognitive impairment and symptoms of depression among geriatric patients in a tertiary care unit in Sri Lanka

Rodrigo, C.; Perera, S.; Adhikari, M.; Rajapakse, A.; Rajapakse, S. (2010)
A two-year retrospective analysis of renal transplant patients in Sri Lanka

Rodrigo, C.; Sheriff, R.; Rajapakse, S.; Lanerolle, R.D.; Sheriff, R. (2011)

This retrospective analytical study aimed at making a database of patients who underwent renal transplant from 31 December 2004 to 31 December 2006 under the Faculty of Medicine renal transplant program. The objective ...
Current evidence on the use of antifilarial agents in the management of bancroftian filariasis

Fernando, S.D.; Rodrigo, C.; Rajapakse, S. (2011)

Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. ...
Hypothyroidism causing paralytic ileus and acute kidney injury - case report

Rodrigo, C.; Gamakaranage, C.S.; Epa, D.S.; Gnanathasan, A.; Rajapakse, S. (2011)

We present a patient with severe hypothyroidism complicated by paralytic ileus and acute kidney injury. A 65 year old male patient, diagnosed with hypothyroidism one year ago was transferred to our unit in a state of ...
Work-related complaints of arm, neck and shoulder among computer office workers in an Asian country: prevalence and validation of a risk-factor questionnaire

Ranasinghe, P.; Perera, Y.S.; Lamabadusuriya, D.A.; Kulatunga, S.; Jayawardana, N.; Rajapakse, S.; Katulanda, P. (2011)

BACKGROUND: Complaints of arm, neck and/or shoulders (CANS) affects millions of computer office workers. However its prevalence and associated risk factors in developing countries are yet to be investigated, due to non ...
Hypokalemic paralysis associated with cystic disease of the kidney: case report

Gamakaranage, C.S.; Rodrigo, C.; Jayasinghe, S.; Rajapakse, S. (2011)

BACKGROUND: Severe hypokalemia is known to cause muscle paralysis, and renal tubular acidosis is a recognized cause. Cystic disease of the kidney is associated with severe hypokalemia. CASE PRESENTATION: We report a ...
Dengue shock

Rajapakse, S. (2011)

Shock syndrome is a dangerous complication of dengue infection and is associated with high mortality. Severe dengue occurs as a result of secondary infection with a different virus serotype. Increased vascular permeability, ...
Characteristics and management patterns of patients admitted with Fever and thrombocytopenia to an acute general medical unit in Sri Lanka

Ibrahim, S.; Horadagoda, C.; Maithripala, C.; Lokunarangoda, N.; Ranasinghe, G.; Wickramarathne, T.; Rajapakse, S. (2011)
Chemoprophylaxis in malaria: drugs, evidence of efficacy and costs

Fernando, S.D.; Rodrigo, C.; Rajapakse, S. (2011)

This review concentrates on different aspects of malaria chemoprophylaxis, namely drug combinations, resistance, impact of malaria prevention in pregnancy and cost effectiveness. A MEDLINE search was performed for all ...
Preliminary audit on early identification and management of chronic kidney disease in adults in an acute general medical unit in Sri Lanka

De Silva, S.; Weerasinghe, D.; Rajapakse, A.; Maithripala, C.; Rajapakse, S. (2011)

This was the first round of an audit to analyze how closely the National Institute of Clinical Excellence (NICE) guidelines on early identification and management of chronic kidney disease in adults is adhered to by a ...

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