Abstract:
In view of increasing incidence of chronic renal failure
in Sri Lanka and demand for transplantation, it is important to evaluate the
outcome of current transplant programmes. Methods: This retrospective analytical
study made a database of patients who underwent renal transplant under the
Faculty of Medicine (Colombo) renal transplant programme during the two year
period from 31st December 2004 to 31st December 2006. Statistical analysis was
done using SPSS. Results / Discussions: There were a total of 73 (n=73) patients
transplanted in the given time period, 46 (62.5 %) at National Hospital and 27
(37.5 %) at Western infirmary. Eighteen (29.1 %) had died by February 2007 of
all patients traced. Forty three patients (58.3%) were interviewed and twelve
patients could not be contacted. Of the interviewed, 28 (38.9%) were on
azathioprin, prednisolone and cyclosporin while 15 (20.8%) were on prednisolone,
cyclosporine and mycophenolate mofetil. In the sample, 4 patients had
cytomegalovirus (CMV) and 5 had tuberculosis (TB) post transplant. Out of all
infections, the most commonly reported one was urinary tract infection (11 cases).
There was no significant benefit in protection against acute rejection in those who
took induction therapy. There was no statistically significant difference in surgical
complications or survival depending on center of transplant. Conclusion: The
numbers were too small to calculate a statistically significant vulnerability to
infections depending on immunosuppressant regimen. Those who received
induction therapy did not have a significantly low rate of acute rejection than
others.
