Abstract:
:The quality of renal allograft function was assessed by prospective
measurement of creatinine clearance at 1 year (n = 197) and at 3 years (n = 115)
after cadaveric renaltransplantation in a cohort of 268 patients treated with triple
therapy immunosuppression.Donor age (P < 0.0012) and recipient age (P < 0.01)
were independently associated with creatinine clearance both at 1 and at 3 years.
In patients with donor age above 50 years and recipient age above 45 years, the
mean creatinine clearance was 32.7 (SD 10.4) ml/min (n = 27). When the donor
age was below 30 years and recipient age below 45 years, the mean creatinine
clearance was 55.6 (SD 14.4) ml/min (n = 47, P < 0.001). However, in these
patients there was no significant association between graft function and many of
the factors known to influence graft survival, such as HLA matching, sensitisation
of the recipient, and the occurrence of rejection. In conclusion, the quality of renal
allograft function declined with increasing donor and recipient age in our patients,
whilst immunological factors were not significantly associated with function in
surviving grafts.
