Abstract:
Ten patients in advanced renal failure with clinical evidence of
septicaemia and positive bacteria isolates from peritoneal dialysate were treated
with gentamicin as the aminoglycoside of choice. Two of these patients had to be
given netilmicin when gentamicin resistance was obseryed. One patient was
placed on tobramycin when she had a gentamicin resistant Pseudomonas
aeruginosa isolated from the dialysate. Eight patients responded to therapy with
clinical recovery. Nephrotoxicity was not observed. Appropriately chosen
aminoglycosides, when carefully monitored, are effective and safe in patients with
severely impaired renal function.
