Abstract:
Idiopathic Membranous Nephropathy is common glomerular
disease in adults and occurs world wide. Various treatment protocols including
high dose alternate day steroids, cyclophosphamide had been used with varying
success rates. The ponticelli regimen has replaced above methods of treatment
and today is widely accepted as a successful treatment regimen in Idiopathic
Membrane Nephropathy. The treatment regime consists of monthly
corticosteroids alternating with chlorambucil (0.2mg per kilogram of body weight
per day) for six months. Monthly steroid treatment consists of methyl
prednisolone in 1 gram pulses for three days. Followed by oral prednisolone (0.5
mg per kilogram of body weight per day) for days. Our patient was started on
treatment in August 1990 and his clinical course is described. This regimen has
not been reported previously in Sri Lanka.
