Recently added

Genetic Determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women.

Sirisena, Nirmala; Kuruppu, Anchala; Adeyemo, Adebowale; Neththikumara, Nilaksha; Samaranayake, Nilakshi; Dissanayake, Vajira H. W. (2017)

Pattern of use of medical information made available via an Internet website.

Dissanayake, V.H.W.; Jayasekara, R.W. (1999)

INTRODUCTION: The Internet is probably the fastest growing means of public communication. Those who seek health and medical information are using it increasingly. We decided to study the pattern of use of information made ...

Establishing a twin register in Sri Lanka

Sumathipala, A.; Fernando, D.J.S.; Siribaddana, S.H.; Abeysingha, M.R.N.; Jayasekara, R.W.; Dissanayake, V.H.W.; De Silva, N. (2000)

Nearly all twin registers are based in developed countries and there is no twin register in the developing world. Our objectives were to initiate the process of establishing a nationwide twin register in Sri Lanka by ...

Prenatal testing and pregnancy termination in Sri Lanka: views of medical students and doctors.

Simpson, B.; Dissanayake, V.H.W.; Wickramasinghe, D.; Jayasekara, R.W. (2003)

INTRODUCTION: Prenatal diagnosis and pregnancy termination generate complex ethical issues. Surveys conducted in Sri Lanka among doctors and medical students in 1986 supported a change in law in favour of pregnancy termination ...

The urine protein heat coagulation test - A useful screening test for proteinuria in pregnancy in developing countries: A method validation study

Dissanayake, V.H.W.; Morgan, L.; Pipkin, F.B.; Vathanan, V.; Premaratne, S.; Jayasekara, R.W.; Seneviratne, H.R. (2004)

In many parts of the developing world, the urine protein heat coagulation test is routinely used to screen for proteinuria in pregnancy. The aim of this study was to determine whether ≥1+ on a standardised heat coagulation ...

Contemplating choice: Attitudes towards intervening in human reproduction in Sri Lanka

Simpson, B.; Dissanayake, V.H.W.; Jayasekara, R.W. (2005)

To date, relatively little is known about the ethical, legal and social responses to recent advances in reproductive and genetic technology outside of Europe and North America. This article reports on a survey carried out ...

Morbidity and mortality associated with pre-eclampsia at two tertiary care hospitals in Sri Lanka

Dissanayake, V.H.W.; Samarasinghe, H.D.; Morgan, L.; Jayasekara, R.W.; Seneviratne, H.R.; Pipkin, F.B. (2007)

Aim: To report the occurrence of morbidity and mortality associated with carefully phenotyped pre-eclampsia in a sample of nulliparous Sinhalese women with strictly defined disease. Methods: A phenotyping database of 180 ...

Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans

Dissanayake, V.H.W.; Tower, C.; Broderick, A.; Stocker, L.J.; Seneviratne, H.R.; Jayasekara, R.W.; Kalsheker, N.; Pipkin, F.B.; Morgan, L. (2007)

Birthweight predicts health later in life and is influenced by inherited factors. We investigated the association of the c.61G > A, and c.2566G > A polymorphisms in the epidermal growth factor (EGF) gene [GenBank NM_01963] ...

Clinical manifestations of cutaneous leishmaniasis in Sri Lanka - Possible evidence for genetic susceptibility among the Sinhalese

Samaranayake, T.N.; Dissanayake, V.H.W.; Fernando, S.D. (2008)

Human cutaneous leishmaniasis (CL) caused by Leishmania donovani, a pathogen more usually associated with visceral leishmaniasis, is now endemic in Sri Lanka. This report details the characteristics of 200 patients with ...

A study of three candidate genes for pre-eclampsia in a Sinhalese population from Sri Lanka

Dissanayake, V.H.W.; Giles, V.; Jayasekara, R.W.; Seneviratne, H.R.; Kalsheker, N.; Pipkin, F.B.; Morgan, L. (2009)

Aim: The aim of these investigations was to study three candidate genes for pre-eclampsia - epidermal growth factor (EGF), transforming growth factor alpha, and angiotensinogen - in pregnant Sinhalese women from Sri Lanka, ...

Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population - implications for association study design and clinical genetic testing services

Dissanayake, V.H.W.; Weerasekera, L.Y.; Gammulla, C.G.; Jayasekara, R.W. (2009)

We investigated the prevalence of genotypes/alleles of single nucleotide polymorphisms (SNP) and haplotypes defined by them in three genes in which variations are associated with venous thromboembolism in 80 Sinhalese, 80 ...

Candidate gene study of susceptibility to cutaneous leishmaniasis in Sri Lanka

Samaranayake, T.N.; Fernando, S.D.; Dissanayake, V.H.W. (2010)

Objectives To investigate the association between selected single nucleotide polymorphisms (SNPs) in TNF, LTA and SLC11A1 genes and risk of endemic cutaneous leishmaniasis (CL) in Sri Lanka through a case-control disease ...

A Sri Lankan child with 49,XXXXY syndrome

Dissanayake, V.H.W.; Giles, V.; Bandarage, P.; Pedurupillay, C.R.J.; Jayasekara, R.W. (2010)

Pentasomy 49,XXXXY is a rare sex chromosome disorder usually presenting with ambigous genitalia, facial dysmorphism, mental retardation and a combination of cardiac, skeletal and other malformations. The incidence of the ...

Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka

Dissanayake, V.H.W.; Wettasinghe, T.K.; Jayasekara, R.W. (2010)

Many advances have been made in reproductive medicine, yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. ...

Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans