Abstract:
This study is a retrospective analysis of cases of carcinoma of rostate.)ne objective of study
is to analyze the epidenuo ogy, presentation, prognostic variables and the treatment offered
in one ~olOgy umt m NatIOnal Cancer InstItute Maharagam. Further to get an insight into
possible fu_rther development in improving quality of care in futurePatient population was
identified through search into patients clinical records maintained at the medical record
room National Cancer Institute Maharagama.Median number of cases per year was 34;
average age was 71.4 years; 67 percentage cases were from Western province; Commonest
presenting symptom was dysurea and frequency; No statistically significant difference of
incidence of prostate cancer in different ethnic groups in Sri Lanka (P=0.01) 48 percent
cases had associated other comorbidities average presenting PSA value was 97 4ng/ml;
majority of patients ( 56 percent) had a Gleason score between 7-10, 36 percent cases as
localized disease and 34 percent cases as metastatic disease , and metastatic status was not
assessed in 30 percent of cases out of these 77.4 percent had PSA more than 20ng/ml. No
correlation between age and PSA (p=o.5), age and Gleason score (p=O.65) or PSA and
Gleason score(p+0.23). In contrast there was signicant relationship between increasing
presenting PSA and presence of metastases ( p=<O,OO1) and Gleason score and presence
of metastases ( p.O.OO1). Radical treatment was offered for 38 percent cases, 56 percent
cases were offered palliative treatment. Radical radiotheraphy was the mode of radical
theraphy in 92.5 percent of cases, 96.5 percent of palliative treatment was orchiectomy, Non
surgical and rogen deprivation therapy was uses in 5 percent of radically treated cases and
10 percent of palliatively treated cases only. Sub group analysis of radically treated cases
showed no statistically significant correlation between increasing PSA and recurrence tate
(p=0.34) or increase in Gleason score and recurrence rate (p=0.81)
