Effectiveness of 400 ug vaginal misoprostol as compared with 800 ug vaginal misoprostol in the management of missed miscarriage

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dc.contributor.author Wansapura, K.S
dc.date.accessioned 2011-12-14T04:19:55Z
dc.date.available 2011-12-14T04:19:55Z
dc.date.issued 2009
dc.identifier.citation MD ( Obstetrics and Gynecology) en_US
dc.identifier.uri http://archive.cmb.ac.lk:8080/xmlui/handle/70130/1454
dc.description.abstract Vaginal misoprostol has shown to be effective and safe in the management of missed miscarriage. However since the optimum dose for that indication is not established, in this study our aim was to find out a cost effective dose of misoprostol for the management of missed miscarriage in our setting. To compare effectiveness and safety of two misoprostol regimes (400 llg versus 800 ug vaginal misoprostol) for the management of missed miscarriage :A randomized controlled trial carried out at the Professorial Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka for a period of 8 months commencing 151 July 2007. One hundred and eighty four women with missed miscarriage between 8 to 20 weeks of POA were randomized to receive 40011g or 80011g vaginal misoprostol. The 'principle outcome measures were success of misoprostol treatment, completeness of medical evacuation, need for surgical evacuation, patient satisfaction and side effects. Comparison of vaginal misoprostol, 80011g and 40011g doses in management of missed miscarriage, revealed that there was no statistically significant difference in success ( p value=O.35), completeness of evacuation( p value=O.38), need for surgical evacuation( p value=O.38) and also patient satisfaction( p value=0.25). Though there was more success and completeness of evacuation noted with 800~Lg dose in earlier gestations (S12weeks) compared with 400flg dose, it did not reach statistical significance( p value=0.06 and 0.05). Further, the dose of 800llg was more successful in the management of early gestations (::;12w) as compared with later gestations which was statistically significant (p value=O.02). The common side effects were compared between the two groups. There was no statistically significant difference between the two groups regarding the occurrence of diarrhoea, vomiting fever or abdominal pain. However the percentages of all side effects are higher in the 800~lg group as compared with 400flg group. Management of missed miscarriage by uSll1g vaginal misoprostol, both 800llg and 400~lg doses are equally effective considering success, completeness of evacuation, need for surgical evacuation and also patient satisfaction. Although there was no statistical proof ,the results of this study is tempting to favour 800llg over 400~lg dose regarding success and rate of complete evacuation for early gestations (PO A ::;12w).There is no statistically significant difference in the common side effects (PY pleading, diarrhoea, vomiting, fever and abdominal pain) between 2 doses. However the frequency of all observed side effects were less with 400flg dose. For the management of missed miscarriage when the POA 12weeks 400 ug dose of vagInal misoprostol can be recommended as a better cost effective and safe regimen compared with 80 ug dose
dc.language.iso en en_US
dc.title Effectiveness of 400 ug vaginal misoprostol as compared with 800 ug vaginal misoprostol in the management of missed miscarriage en_US
dc.type Research abstract en_US


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