This randomized trial was undertaken to test the influence of neo-adjuvant chemotherapy on
the local control of advanced carcinoma of oral cavity and oropharynx,when given with
radiotherapy.In this trial cis-platin based combination chemotherapy and radiotheraphy arm
was tested against radiation only arm.24 patient were enrolled into this randomized trial.The
patients were randomized by assigning them alternatively to either arms.Inclusion criteria
were histologically proven squamous cell carcinoma of oral cavity or oropharynx,stage
T3/T4 or N2/N3 disease,performance status of 2 or less and normal renal function test and
normal WBC/DC count.All patients with the lesions in the oropharynx and some patient
with lesions in the oral cavity presented to our institute with histologically confirmed
squamous cell carcinoma.In others histological cofiramation was obtained using a punch
biopsy specimen.All patients except one completed scheduled therapy without any
interruption or alteration in the treatment schedule.The one who had not competed the
schedule thetapy was lost following chemotherapy.Remaining all 23 patients were followedup until 3 months after completion of treatment for the purpose of this study
