Abstract:
This study was initiated to determine the part played by cell mediated immunity in patients
with dermatophyte infections.Three groups of individuals were studied. A "control"
group,"acute" group identified as having dermatophyte infections for less than six months
and a "chronic" group of 15 individuals having dermatophyte infections of over six
months.The acute and chronic patient groups had the dermatophytes identified by the
standard method of culture.Trichophyton rubrum,the commonest dermatophyte isolated in
the mycology laboratories and which caused chronic infections,was isolated in all the
patients who had dermatophyte infections of more than six months duration.The absolute
CD4 cell count was low in the chronically infected group.The E-rosettes are formed by all
T-lymphocytes with CD2 makers.A low T-lymphocyte count in turn lowers the cell
mediated immunity leading to persistence of the infection in the chronically infected
patients.In this study the chronically infected group showed a higher rate of tuberculin
negativity indicating a lowered cell mediated immunity,giving rise to a persistence of the
infection.These findings suggest that the patients who had chronic dermatophyte infections
were having lowered cell mediated immunity which is consistant with the findings of
previous studies.
