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dc.contributor.authorKudahewa, D.D.-
dc.contributor.authorAbeytunga, D.T.U.-
dc.contributor.authorRatnasooriya, W.D.-
dc.identifier.citationD.D. Kudahewa, D.T.U. Abeytunga, W.D. Ratnasooriya. Antinociceptive activity of Pleurotus cystidiosus, an edible mushroom in rats. Pharmacognosy Magazine, 2008, 4(13): 37- 41.en_US
dc.description.abstractThe antinociceptive potential of Pleurotus cystidiosus, an edible mushroom (family: Tricholomataceae) was investigated in male rats (doses used: 125, 500, and 1000 mg/kg) and female rats in the di-oestrous stage using the standard hot plate and tail flick tests. In the hot plate test, the reaction time was significantly (P < 0.05) prolonged in male rats after 2 h of administration (18 % mid and 93% high dose). The di-oestrous female rats also showed significant (P < 0.05) prolongation in the reaction time on the hot plate test (22 %) upon administration of the high dose. This antinociceptive activity had the peak effect at 2 h in male rats and the activity was dose dependent (r2 = 0.81, p < 0.05). In contrast, none of the rats showed an increase in reaction time in the tail-flick test. The acetone and methylene chloride extracts of P. cystidiosus was also orally administered to the rats and antinociceptive activity investigated. Only the acetone extract showed a marked and significant increase in reaction time on the hot plate test at 2 h (23% mid and 49% high dose). We conclude that the acetone extract retain the pain alleviating properties, however the whole mushroom has a better effect with 1000 mg/kg dose.en_US
dc.publisher. Pharmacognosy Magazineen_US
dc.subjectHot plate, Morphineen_US
dc.subjectPleurotus cystidiosusen_US
dc.subjectPleurotus cystidiosusen_US
dc.subjectTail flick methoden_US
dc.titleAntinociceptive activity of Pleurotus cystidiosus, an edible mushroom in ratsen_US
dc.typeResearch abstracten_US
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