Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7340
Title: Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder
Authors: Weerakoon, W.A.S.S.
Perera, P.K.
Gunasekera, D.
Suresh, T.S.
Keywords: In Vitro antioxidant
In Vivo antioxidant
Sudarshana Powder
paediatricfebrilecondition
Issue Date: 2018
Publisher: Evidence-Based Complementary and Alternative Medicine
Citation: Weerakoon, W.A.S.S., Perera, P.K., Gunasekera, D., & Suresh, T.S. (2018). Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/6743862.
Abstract: Sudarshana powder (SP) is one of the most effective Ayurveda powder preparations for paediatric febrile conditions. The objective of the present study was to evaluate the in vitro and in vivo antioxidant potentials of SP. The in vitro antioxidant effects were evaluated using ABTS radical cation decolourization assay where the TROLOX equivalent antioxidant capacity (TEAC) was determined. The in vivo antioxidant activity of SP was determined in Wistar rats using the Lipid Peroxidation (LPO) assay in serum. The in vitro assay was referred to as the TROLOX equivalent antioxidant capacity (TEAC) assay. For the in vivo assay, animals were dosed for 21 consecutive days and blood was drawn to evaluate the MDA level. The in vitro antioxidant activity of 0.5 𝜇g of SP was equivalent to 14.45 𝜇g of standard TROLOX. The percentage inhibition against the radical formation was 50.93 ± 0.53%. The SP showed a statistically significant (𝑝 < 0.01) decrease in the serum level of thiobarbituric acid-reactive substance in the test rats when compared with the control group. These findings suggest that the SP possesses potent antioxidant activity which may be responsible for some of its reported bioactivities.
URI: https://doi.org/10.1155/2018/6743862
http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7340
Appears in Collections:Department of Ayurveda Pharmacology, Pharmaceutics and Community Medicine

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