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Title: | Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant |
Authors: | Pallie, M.S. Perera, P.K. Goonasekara, C.L. Kumarasinghe, K.M.N. Arawwawala, L.D.A.M. |
Keywords: | Tragia spp Diuresis Phytochemicals Standardization |
Issue Date: | 2017 |
Publisher: | American Journal of Ethnomedicine |
Citation: | Pallie, M.S., Perera, P.K., Goonasekara, C.L., Kumarasinghe, K.M.N., and Arawwawala, L.D.A.M. (2017). Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant. American Journal of Ethnomedicine, 4(1:5). https://doi.org/10.21767/2348-9502.100005 |
Abstract: | Background: Due to several toxic effects of synthetic diuretics drugs, people relay of medicinal plants as a source of diuretics. Hence, the efficacy of Tragia spp. which belonging to plant family Euphorbiaceae is an important medicinal plant used as a diuretic in Sri Lanka. Objective: The aim of the present study was to investigate diuretic activity and standardize whole plant of Tragia spp. Materials and methods: Plant extract (doses of 550, 1100, 1650, 2200 mg/kg), vehicle (2 ml of distilled water), reference drug (furosemide at 13 mg/kg) were given orally to separate groups of Wistar male rats (N = 6). In order to assess the diuretic activity, urine output was measured hourly for five hours. Na+ and K+ content, specific gravity, pH of urine measured in all groups. Whole plant of Tragia spp. was standardized in terms of physico-chemical parameters, phytochemical screening and antioxidant activity. Results: Results revealed that urine output of rats were significantly (P<0.05) increased when increasing the dose of Tragia spp. extract. Diuretic activity was initiated in the first hour and declined with time. Diuresis was maximum at the 1 h and at a dose of 2200 mg/kg urine output was significantly (P<0.05) higher than the reference drug. Tragia spp. extract also triggered a clear increase in Na+ and K+ levels and decreased pH levels in urine. Physico-chemical parameters, phytochemical screening and antioxidant activity were determined in order to standard Tragia spp. Conclusion: Tragia spp. exhibit marked diuretic activity and its mechanism of action is similar to a loop diuretic drug. Further, establishment of standardization parameters of Tragia spp. will help in correct identification and prevent adulteration. |
URI: | https://doi.org/10.21767/2348-9502.100005 http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7329 |
ISSN: | 2348-9502 |
Appears in Collections: | Department of Ayurveda Pharmacology, Pharmaceutics and Community Medicine |
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