Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7329
Title: Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant
Authors: Pallie, M.S.
Perera, P.K.
Goonasekara, C.L.
Kumarasinghe, K.M.N.
Arawwawala, L.D.A.M.
Keywords: Tragia spp
Diuresis
Phytochemicals
Standardization
Issue Date: 2017
Publisher: American Journal of Ethnomedicine
Citation: Pallie, M.S., Perera, P.K., Goonasekara, C.L., Kumarasinghe, K.M.N., and Arawwawala, L.D.A.M. (2017). Tragia spp: Assessment of Diuretic Activity and Standardization of the Whole Plant. American Journal of Ethnomedicine, 4(1:5). https://doi.org/10.21767/2348-9502.100005
Abstract: Background: Due to several toxic effects of synthetic diuretics drugs, people relay of medicinal plants as a source of diuretics. Hence, the efficacy of Tragia spp. which belonging to plant family Euphorbiaceae is an important medicinal plant used as a diuretic in Sri Lanka. Objective: The aim of the present study was to investigate diuretic activity and standardize whole plant of Tragia spp. Materials and methods: Plant extract (doses of 550, 1100, 1650, 2200 mg/kg), vehicle (2 ml of distilled water), reference drug (furosemide at 13 mg/kg) were given orally to separate groups of Wistar male rats (N = 6). In order to assess the diuretic activity, urine output was measured hourly for five hours. Na+ and K+ content, specific gravity, pH of urine measured in all groups. Whole plant of Tragia spp. was standardized in terms of physico-chemical parameters, phytochemical screening and antioxidant activity. Results: Results revealed that urine output of rats were significantly (P<0.05) increased when increasing the dose of Tragia spp. extract. Diuretic activity was initiated in the first hour and declined with time. Diuresis was maximum at the 1 h and at a dose of 2200 mg/kg urine output was significantly (P<0.05) higher than the reference drug. Tragia spp. extract also triggered a clear increase in Na+ and K+ levels and decreased pH levels in urine. Physico-chemical parameters, phytochemical screening and antioxidant activity were determined in order to standard Tragia spp. Conclusion: Tragia spp. exhibit marked diuretic activity and its mechanism of action is similar to a loop diuretic drug. Further, establishment of standardization parameters of Tragia spp. will help in correct identification and prevent adulteration.
URI: https://doi.org/10.21767/2348-9502.100005
http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7329
ISSN: 2348-9502
Appears in Collections:Department of Ayurveda Pharmacology, Pharmaceutics and Community Medicine

Files in This Item:
File Description SizeFormat 
tragia-spp-assessment-of-diuretic-activity-and-standardization-of-the-whole-plant.pdf374.59 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.